Cognitive behavioral therapy positively affects fatigue in patients with multiple sclerosis: Results of a randomized controlled trial

Multiple Sclerosis : Clinical and Laboratory Research
Lizanne E van den AkkerTREFAMS-ACE Study Group

Abstract

Fatigue is a common symptom in multiple sclerosis (MS) and often restricts societal participation. Cognitive behavioral therapy (CBT) may alleviate MS-related fatigue, but evidence in literature is inconclusive. To evaluate the effectiveness of CBT to improve MS-related fatigue and participation. In a multi-center, assessor-masked, randomized controlled trial, participants with severe MS-related fatigue were assigned to CBT or control treatment. CBT consisted of 12 individual sessions with a psychologist trained in CBT, the control treatment consisted of three consultations with a MS nurse, both delivered over 16 weeks. Assessments were at baseline, 8, 16 (i.e. post-intervention), 26, and 52 weeks post-baseline. Primary outcomes were the Checklist Individual Strength-fatigue subscale (CIS20r fatigue) and the Impact on Participation and Autonomy questionnaire (IPA). Data were analyzed according to the intention-to-treat principle, using mixed-model analysis. Between 2011 and 2014, 91 patients were randomized (CBT: n = 44; control: n = 47). Between-group analysis showed a positive post-intervention effect for CBT on CIS20r fatigue (T16: -6.7 (95% confidence interval (CI) = -10.7; -2.7) points) that diminished during follow-up (T5...Continue Reading

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Citations

Mar 20, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Jana PöttgenStefan M Gold
Jan 30, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E L NikolaevA V Golenkov
Aug 31, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Matthew Plow, Marcia Finlayson
Feb 18, 2020·Frontiers in Neurology·Arjan MalekzadehCharlotte E Teunissen
Apr 14, 2018·Journal of Cancer Survivorship : Research and Practice·Lidewij D Van GesselHans Knoop
Apr 27, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Anna L KratzSusan L Murphy
Jan 23, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Mujtaba Husain, Trudie Chalder
Apr 3, 2021·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Line BrochElisabeth Gulowsen Celius
Apr 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Karl M FlemingMatthew P Herring
Apr 21, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Anthony M HarrisonSam Norton
Apr 27, 2021·Frontiers in Psychiatry·XiaoGuang LinZhongQuan Yi
Jul 9, 2021·Multiple Sclerosis and Related Disorders·Tracy E HerringDawn M Ehde
Apr 27, 2020·Journal of the Neurological Sciences·Zeinab FalsafiMohammad Hossein Harirchian
May 8, 2020·Multiple Sclerosis and Related Disorders·Martin HeineWayne Derman

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Methods Mentioned

BETA
blood draw
RAP

Clinical Trials Mentioned

ISRCTN58583714

Software Mentioned

ACE
TIDieR
SPSS

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