Cognitive Burden of Common Non-antiretroviral Medications in HIV-Infected Women

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Leah H RubinJeffrey R Bishop

Abstract

The aging HIV population has increased comorbidity burden and consequently non-antiretroviral medication utilization. Many non-antiretroviral medications have known neurocognitive-adverse effects ("NC-AE medications"). We assessed the cognitive effects of NC-AE medications in HIV+ and HIV- women. One thousand five hundred fifty-eight participants (1037 HIV+; mean age 46) from the Women's Interagency HIV Study completed a neuropsychological test battery between 2009 and 2011. The total number of NC-AE medications and subgroups (eg, anticholinergics) were calculated based on self-report. Generalized linear models for non-normal data were used to examine the cognitive burden of medications and factors that exacerbate these effects. HIV+ women reported taking more NC-AE medications vs. HIV- women (P < 0.05). NC-AE medication use altogether was not associated with cognitive performance. However, among NC-AE medication subgroups, anticholinergic-acting medications, but not opioids or anxiolytics/anticonvulsants, were negatively associated with performance. HIV status moderated the association between these NC-AE medication subgroups and performance (P's < 0.05). HIV-serostatus differences (HIV- < HIV+) in global, learning, fluency, a...Continue Reading

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Citations

Jun 4, 2019·Expert Review of Clinical Pharmacology·Catia Marzolini, Françoise Livio
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rowan SalonerMariana Cherner
Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anjali SharmaLeah H Rubin
Jan 15, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Dionna W WilliamsLeah H Rubin
Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elisa MantovaniStefano Tamburin
Jul 29, 2020·Journal of Neurovirology·Precious AmusanEsther Fujiwara
Sep 3, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sylvia FittingKurt F Hauser
May 12, 2020·Frontiers in Integrative Neuroscience·Leah H RubinDionna W Williams
Dec 22, 2020·Current Treatment Options in Infectious Diseases·Tessa Del CarmenEugenia L Siegler
Feb 23, 2021·Lancet·Adaora A AdimoraMonica Gandhi
Mar 9, 2021·Frontiers in Neurology·Raha M DastgheybLeah H Rubin
Jul 6, 2020·The Lancet. HIV·Alan Winston, Serena Spudich
Apr 9, 2021·The American Journal of Clinical Nutrition·Leah H RubinSheri D Weiser
Apr 24, 2021·British Journal of Clinical Pharmacology·Andrea CalcagnoStefano Bonora

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