Cognitive Changes in Peritoneal Dialysis Patients: A Multicenter Prospective Cohort Study

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Yu-Hui ZhangJie Dong

Abstract

Cognitive impairment is an independent predictor of technique failure and mortality in patients on peritoneal dialysis (PD) therapy. We investigated changes in cognitive function and factors associated with it in this population. Multicenter prospective cohort study. 458 PD patients were enrolled and followed up for 2 years. Global and specific domains of cognitive function were measured at baseline and after 2 years. The Modified Mini-Mental State Examination (3MS) was used for assessment of global cognitive function; Trail-Making Tests A and B, for executive function; and subtests of the Battery for the Assessment of Neuropsychological Status, for immediate and delayed memory, visuospatial skill, and language ability. The primary outcome was change in cognitive function. Secondary outcomes included all-cause mortality, cardiovascular mortality, hospitalization, and transition to hemodialysis therapy. Multivariable linear regression models. The prevalence of cognitive impairment increased from 19.8% to 23.9%. 3MS scores significantly decreased (84.8 to 83.1), although executive function, immediate memory, and visuospatial skill improved over time. Delayed memory capacity and language ability were unchanged. Lower serum albumin...Continue Reading

Citations

Nov 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dearbhla M Kelly
Sep 11, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Xue-Dan NieJie Dong
Sep 13, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Dearbhla Kelly, Peter Malcolm Rothwell
May 8, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Camilla Maroni Marques Freire de MedeirosAlexandre Braga Libório
Jul 23, 2020·Clinical Kidney Journal·Zhikai Yang, Jie Dong
Mar 25, 2019·Seminars in Dialysis·Nadia M Chu, Mara A McAdams-DeMarco
Jul 14, 2020·Journal of Clinical Neurology·Bong Soo ParkKang Min Park
Jun 30, 2019·Clinical and Experimental Nephrology·Yat-Fung SheaTak Mao Chan
Nov 18, 2020·Psychiatry Investigation·Dong Jin ShinYunmi Kim
Mar 30, 2021·Current Transplantation Reports·Nadia M ChuMara A McAdams-DeMarco
Jun 2, 2021·The International Journal of Artificial Organs·Taisuke KitanoYoshiyuki Morishita
Aug 11, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Noé A Salazar-FélixLaura Cortés-Sanabria
Sep 23, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Jun-Jie ZhuPing Zhou
Aug 23, 2019·Respiration; International Review of Thoracic Diseases·Mareye VoortmanJolanda De Vries

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