Cognitive decision modelling of emotion-based learning impairment in schizophrenia: the role of awareness

Psychiatry Research
Matteo CellaOliver H Turnbull

Abstract

Individuals with schizophrenia often lack insight or awareness. Resulting impairment has been observed in various cognitive domains and, recently, linked to problems in emotion-based learning. The Iowa Gambling Task (IGT) has been used to assess emotion-based decision-making in patients with schizophrenia, but results have been inconclusive. The current study further investigates emotion-based decision-making in schizophrenia by elucidating the unique contribution of awareness. Twenty-five patients with schizophrenia and 24 healthy controls were assessed with a modified version of the IGT recording awareness at regular intervals. Symptom assessment, medication and medical history were recorded for the clinical group. Patients with schizophrenia underperformed on the IGT compared to controls. Subjective awareness levels were significantly lower in the schizophrenia group and were associated with hallucination severity. Cognitive decision modelling further indicated that patients with schizophrenia had impaired attention to losses, compared to controls. This parameter was positively correlated with awareness. We also found that positive symptoms altered awareness levels and suggest that this disruption may contribute to sub-optim...Continue Reading

References

Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R Damasio
Feb 28, 1997·Science·A BecharaA R Damasio
Jul 23, 1998·Neuropsychology·R W Heinrichs, K K Zakzanis
Nov 11, 2003·Brain and Cognition·Oliver H TurnbullCaroline H Bowman
Mar 24, 2004·Neuropsychologia·Aikaterini FotopoulouOliver Turnbull
Mar 24, 2004·Schizophrenia Research·Laura M RitterGregory W Dalack
Mar 31, 2004·Brain and Cognition·Cathryn E Y EvansOliver H Turnbull
Jun 30, 2004·Brain and Cognition·Oliver H TurnbullCathryn E Y Evans
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tiago V Maia, James L McClelland
Jan 7, 2005·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Oliver H TurnbullVanessa Owen
Apr 6, 2005·Trends in Cognitive Sciences·A BecharaA R Damasio
Oct 4, 2005·Neuroscience and Biobehavioral Reviews·Barnaby D DunnAndrew D Lawrence
May 31, 2006·Schizophrenia Research·Hana M KesterSanjiv Kumra
Jul 14, 2006·Schizophrenia Research·Mujeeb U ShadMatcheri S Keshavan
Mar 14, 2007·Cognitive Neuropsychiatry·Andor E SimonSylvia Mohr
Apr 13, 2007·Neuropsychologia·Aikaterini FotopoulouMark Solms
May 18, 2007·Psychiatry Research·Diego J MartinoRicardo F Allegri
Jul 14, 2007·Brain and Cognition·Michael N Dretsch, Jason Tipples
Feb 29, 2008·Neuropsychologia·Aikaterini FotopoulouMichael Kopelman
Jun 24, 2009·Journal of Clinical and Experimental Neuropsychology·Simon DymondOliver H Turnbull
Nov 17, 2009·Brain and Cognition·Eldad YechiamJudith Aharon
Dec 22, 2009·Schizophrenia Research·Marion LarquetFlorence Thibaut
Sep 21, 2010·Schizophrenia Bulletin·J GilleenA S David

❮ Previous
Next ❯

Citations

Dec 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daisuke MatsuzawaMasaomi Iyo
May 25, 2013·Journal of Clinical and Experimental Neuropsychology·Eileen M MartinAntoine Bechara
Mar 10, 2015·Addictive Behaviors·Zoe BriggsRobert Whelan
Jun 2, 2016·Europe's Journal of Psychology·Melissa J Hawthorne, Benton H Pierce
Jan 21, 2020·Applied Neuropsychology. Adult·Kenny A KaryadiWilliam G Britt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.