Cognitive decline and education in mild dementia

Neurology
F W UnverzagtH C Hendrie

Abstract

Recent studies suggested that education may modify the clinical expression of dementia and Alzheimer's disease through its association with a brain reserve capacity. We studied whether education would be related to degree of cognitive decline in mild dementia. Equations to estimate premorbid cognitive ability were derived from a representative normative sample of 83 community-dwelling African Americans using age, education, and gender as independent variables and Word List Learning (WLL) and Animal Fluency (AF) scores from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery as dependent variables. These equations were applied to a second sample of 131 African Americans (22 with dementia, 109 healthy) who completed CERAD test batteries as part of an epidemiologic study of dementia in the community. Differences between obtained and estimated premorbid WLL and AF test scores were calculated and then analyzed in a 2 (Education) x 2 (Diagnosis) ANOVA. A significant interaction association between Education and Diagnosis on WLL scores and a borderline significant interaction on AF scores showed that the high-education demented group had a greater cognitive decline from estimated prem...Continue Reading

References

Jan 1, 1991·Neurology·J F KurtzkeM A Smith
Mar 1, 1991·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·F BollerK L McGonigle-Gibson
Jan 1, 1988·Neurology·R J BartlettE Bakker
Jan 1, 1995·The American Journal of Psychiatry·M Viederman
Jan 1, 1994·Neurology·M J KupersmithJ Whitaker

❮ Previous
Next ❯

Citations

Feb 9, 2002·Annals of Neurology·Emma HocklyGillian P Bates
Jul 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Haruo HanyuKiyoshi Koizumi
Apr 12, 2011·Brain : a Journal of Neurology·Prashanthi VemuriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·N ScarmeasY Stern
Nov 21, 2007·Dementia and Geriatric Cognitive Disorders·Laura BraccoSandro Sorbi
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·R P FriedlandS M Debanne
Mar 11, 2004·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ian A CookSusan Rosenberg
Jul 10, 2008·International Journal of Geriatric Psychiatry·Jenny C C Chung
Apr 6, 2004·Clinics in Geriatric Medicine·Jennifer J Manly, David V Espino
Sep 1, 2015·Frontiers in Aging Neuroscience·Eider M Arenaza-UrquijoGaël Chételat
Feb 21, 2014·International Journal of Psychiatry in Medicine·Stephen R RappUNKNOWN Women's Health Initiative Memory Study
Jun 30, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Keith R LawsTim M Gale
Nov 25, 2005·Journal of Geriatric Psychiatry and Neurology·Jennifer J ManlyYaakov Stern
Jan 1, 2007·Research on Aging·Dawn AlleyEileen Crimmins
Apr 16, 2013·Journal of Geriatric Psychiatry and Neurology·Lara AlvesIsabel Santana
Oct 1, 1998·The New England Journal of Medicine·L P Rowland
Aug 10, 1999·International Journal of Geriatric Psychiatry·C A LuisR Duara
Mar 4, 2005·Journal of Clinical and Experimental Neuropsychology·M E O'ConnellH Kadlec
Aug 11, 2020·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Martin LövdénElliot M Tucker-Drob
Jul 16, 2003·Acta Neurologica Scandinavica·M Karrasch, M Laine
Sep 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Seok Ming LimChristopher C Rowe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.