Cognitive decline and survival in Alzheimer's disease

International Journal of Geriatric Psychiatry
R S WilsonDenis A Evans

Abstract

To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD). A total of 472 persons with clinically diagnosed AD were recruited from a memory disorders clinic and day care centers in the Chicago area. They completed a uniform clinical evaluation at baseline and a battery of nine cognitive tests at six-month intervals for a mean of about three years. A previously established measure of global cognition was derived from the nine tests. During follow-up, 168 persons (36%) died. In a proportional hazards model that controlled for age, sex, race, education, and baseline level of cognition, individual rate of global cognitive decline, estimated with least squares regression, was linearly related to mortality risk. Thus, a person declining minimally (increase of 0.04 unit per year, 90th percentile) was 2.7 times less likely to die during the study period than a person declining rapidly (decrease of 0.76 unit per year, 10th percentile). Controlling for baseline disability did not substantially affect results. The association of cognitive decline with mortality was substantially stronger for white persons compared to African American...Continue Reading

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Oct 13, 2004·Neurology·R S WilsonD A Evans

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Citations

Jun 10, 2009·Archives of Neurology·Robert S WilsonDenis A Evans
Nov 26, 2008·International Psychogeriatrics·Matt ParadiseGill Livingston
Jan 19, 2007·Neuroepidemiology·B M van GelderD Kromhout
May 4, 2007·Dementia and Geriatric Cognitive Disorders·Laure CarcaillonJean-François Dartigues
Nov 29, 2007·Dementia and Geriatric Cognitive Disorders·A BruandetF Pasquier
Apr 15, 2010·Neuroepidemiology·Kyle SteenlandAllan Levey
May 31, 2008·American Journal of Public Health·Karen A ErtelLisa F Berkman
Feb 21, 2018·Alzheimer's Research & Therapy·Hanneke F M Rhodius-MeesterWiesje M van der Flier
Apr 22, 2010·Journal of the American Geriatrics Society·Kristine YaffeUNKNOWN Health, Aging and Body Compsition Study
Jul 30, 2021·International Journal of Geriatric Psychiatry·Melissa CoMatthew Prina

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