PMID: 8584766Nov 1, 1995Paper

Cognitive decline due to aging among persons with Down syndrome

Research in Developmental Disabilities
J P DasJ A Naglieri

Abstract

This study examined decline in cognitive functions in individuals with Down syndrome (DS) over the age of 40 in comparison to participants of the same age and comparable mental handicap without Down syndrome (NonDS). Both DS (n = 32) and NonDS (n = 31) samples were divided into "younger" (40-49 years) and "older" (50-62) groups. Cognitive processes were examined by tests of general intellectual functioning (Dementia Rating Scale, Peabody Picture Vocabulary Test-Revised, and the Matrix Analogies Test-Expanded form), as well as planning, attention, simultaneous, and successive processing tests taken from Das-Naglieri Cognitive Assessment System. The older individuals with Down syndrome performed more poorly than those in the other three groups. The differences were particularly evident in tasks requiring planning and attention. The possibility of using these tests as indicators of the early signs of Alzheimer's disease is discussed.

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Citations

May 4, 2010·Journal of Intellectual Disability Research : JIDR·P WillnerS Dymond
Mar 6, 2010·Journal of Intellectual Disability Research : JIDR·S LanfranchiR Vianello
May 20, 2015·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Julie GriecoAlison Schwartz
Dec 3, 2014·Research in Developmental Disabilities·Jin-Ding LinCordia Chu
Jan 1, 2015·American Journal on Intellectual and Developmental Disabilities·Raphaele Tsao Gerald Bussy
Oct 19, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Jordan Elliott-KingEef Hogervorst
Aug 6, 2016·Journal of Applied Research in Intellectual Disabilities : JARID·Ann McPaulKaren McKenzie
Jul 1, 1997·Journal of Geriatric Psychiatry and Neurology·D S GeldmacherP J Whitehouse
Feb 10, 2018·Journal of Applied Research in Intellectual Disabilities : JARID·Karen McKenzieGeorge Murray
Apr 2, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Eirini Sanoudaki, Spyridoula Varlokosta
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Wayne Silverman
Sep 1, 2019·Journal of Neurodevelopmental Disorders·Sarah HamburgAndré Strydom
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·R S Chapman, L J Hesketh
Jun 15, 2019·American Journal on Intellectual and Developmental Disabilities·Elizabeth SmithChristopher Jarrold
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·K A GyureJ C Troncoso

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