Cognitive deficits develop 1month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge

Brain, Behavior, and Immunity
Megan M MuccigrossoJonathan P Godbout

Abstract

Traumatic brain injury (TBI) elicits immediate neuroinflammatory events that contribute to acute cognitive, motor, and affective disturbance. Despite resolution of these acute complications, significant neuropsychiatric and cognitive issues can develop and progress after TBI. We and others have provided novel evidence that these complications are potentiated by repeated injuries, immune challenges and stressors. A key component to this may be increased sensitization or priming of glia after TBI. Therefore, our objectives were to determine the degree to which cognitive deterioration occurred after diffuse TBI (moderate midline fluid percussion injury) and ascertain if glial reactivity induced by an acute immune challenge potentiated cognitive decline 30 days post injury (dpi). In post-recovery assessments, hippocampal-dependent learning and memory recall were normal 7 dpi, but anterograde learning was impaired by 30 dpi. Examination of mRNA and morphological profiles of glia 30 dpi indicated a low but persistent level of inflammation with elevated expression of GFAP and IL-1β in astrocytes and MHCII and IL-1β in microglia. Moreover, an acute immune challenge 30 dpi robustly interrupted memory consolidation specifically in TBI mi...Continue Reading

References

Jan 24, 1998·Archives of Physical Medicine and Rehabilitation·M RosenthalT P Ross
Jul 20, 2001·The Journal of Head Trauma Rehabilitation·S R MillisJ H Ricker
Feb 5, 2004·Brain, Behavior, and Immunity·Brian M BergRodney W Johnson
Apr 20, 2006·Neuropsychologia·C H SalmondB J Sahakian
Nov 7, 2007·Journal of Neuropathology and Experimental Neurology·Brian Joseph KelleyJohn Theodore Povlishock
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P GodboutRodney W Johnson
Dec 23, 2008·Archives of Physical Medicine and Rehabilitation·Christine TillRobin E Green
Jun 3, 2009·Brain, Behavior, and Immunity·Ruth M BarrientosSteven F Maier
Dec 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bridgette D SempleM Cristina Morganti-Kossmann
Nov 26, 2010·Brain, Behavior, and Immunity·Ofra Ben Menachem-ZidonRaz Yirmiya
Dec 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mazen A Kheirbek, René Hen
Jun 29, 2011·Annals of Neurology·Anil F RamlackhansinghDavid J Sharp
May 3, 2012·Genes & Development·Anna V MolofskyDavid H Rowitch
Jul 31, 2012·Archives of Physical Medicine and Rehabilitation·Tessa HartLisa A Brenner
Jul 31, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Hao-Kuang WangKuen-Jer Tsai
Jan 11, 2013·Journal of Neurotrauma·Michael J HylinPramod K Dash
Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam D BachstetterLinda J Van Eldik
Aug 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric S WohlebJohn F Sheridan
Dec 18, 2013·Journal of Neuropathology and Experimental Neurology·David J LoaneAlan I Faden
Jan 9, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shruti V KabadiAlan I Faden
Mar 13, 2014·Glia·Diana M NordenJonathan P Godbout
Mar 19, 2014·Experimental Neurology·F Rezan SahinkayaDana M McTigue

❮ Previous
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Citations

Apr 28, 2016·CNS Drugs·Edward Lewis Tobinick
Jun 16, 2016·Experimental Neurology·Thomas M ReevesLinda L Phillips
Jul 28, 2016·PloS One·Alex P Di BattistaMichael G Hutchison
Nov 1, 2016·Journal of Neurochemistry·Damon J DiSabatoJonathan P Godbout
Oct 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle H TheusIrving C Allen
Mar 14, 2020·Journal of Neurotrauma·Zoe M TappOlga N Kokiko-Cochran
Mar 17, 2020·Journal of Alzheimer's Disease : JAD·Teodor T PostolacheJohn W Stiller
Aug 24, 2019·Frontiers in Cellular Neuroscience·Saef IzzyMichael J Whalen
Dec 21, 2016·Frontiers in Immunology·Celia A McKee, John R Lukens
Jan 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mikko T HuuskonenKatja M Kanninen
Apr 9, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ruojing BaiPing Lei
Apr 25, 2018·Frontiers in Immunology·Olga N Kokiko-Cochran, Jonathan P Godbout
Sep 14, 2018·Frontiers in Systems Neuroscience·Daria TchessalovaNatalie Celia Tronson
Feb 12, 2020·Journal of Neurotrauma·Stuart J McDonaldFrances Corrigan
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Abhishek WadhawanTeodor T Postolache
Oct 27, 2020·Frontiers in Neurology·Caitlin E BrombergTheresa Currier Thomas
Jan 27, 2021·Trends in Neurosciences·Alan I FadenRebecca J Henry
Oct 31, 2020·Journal of Neuroinflammation·Eric EyolfsonAlexander W Lohman
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Felipe Figueredo SaviCristiane Ritter
Jan 3, 2018·Neurobiology of Learning and Memory·David J TitusColeen M Atkins
Jun 25, 2018·Neurobiology of Disease·Patricia G SalettiAristea S Galanopoulou
Jun 16, 2021·The Journal of Clinical Investigation·Marie HanscomTerez Shea-Donohue
Oct 9, 2017·ACS Biomaterials Science & Engineering·Francesca L MacleanDavid R Nisbet
Aug 10, 2019·ACS Pharmacology & Translational Science·Elliot J GlotfeltyNigel H Greig
Sep 25, 2021·Nature Immunology·Panagiotis MastorakosDorian B McGavern

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