Cognitive Deficits in Older Adults With Psychotic Depression: A Meta-Analysis

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Tom VermeulenErik J Giltay

Abstract

A major depressive disorder with psychotic features, that is, psychotic depression (PD), is often accompanied by cognitive deficits, particularly in older patients. We aimed to assess to what extent various cognitive domains are affected in older patients with PD compared to those with nonpsychotic depression (NPD). Therefore, a systematic search was conducted in Medline, Embase, Web of Science, the Cumulative Index to Nursing and Allied Literature (CINAHL), Google Scholar, and Cochrane for all relevant studies. Hereafter, we conducted a meta-analysis of seven studies on cognitive deficits in older adults (55+ years), comparing patients with PD and patients with NPD. Compared to patients with NPD, those with PD not only showed a significantly poorer performance on overall cognitive function, with a Hedges' g effect size of -0.34 (95% confidence interval: -0.56; -0.12; p = 0.003), but also on nearly all separate cognitive domains, with Hedges' g effect sizes ranging from -0.26 to -0.64 (all p's <0.003), of which attention was most adversely affected. Verbal fluency showed no significant effect, although this analysis may have been underpowered. The funnel plot suggested no significant publication bias (Egger test intercept: -2.4...Continue Reading

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Citations

Mar 11, 2020·Translational Psychiatry·Michael W LutzOrnit Chiba-Falek
Nov 5, 2021·American Journal of Alzheimer's Disease and Other Dementias·Yajing ChengFei Wang

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