Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway

Toxicology
Jing GaoZhuo Yang

Abstract

Multi-walled carbon nanotubes (MWCNTs) have shown potential applications in many fields, especially in the field of biomedicine. Several studies have reported that MWCNTs induce apoptosis and oxidative damage in nerve cells during in vitro experiments. However, there are few studies focused on the neurotoxicity of MWCNTs used in vivo. Many studies have reported that autophagy, a cellular stress response to degrade damaged cell components, can be activated by diverse nanoparticles. In this study, we investigated the neurotoxic effects of MWCNTs on hippocampal synaptic plasticity and spatial cognition in rats. Then, we used an inhibitor of autophagy called chloroquine (CQ) to examine whether autophagy plays an important role in hippocampal synaptic plasticity, since this was damaged by MWCNTs. In this study, adult male Wister rats were randomly divided into three groups: a control group, a group treated with MWCNTs (2.5mg/kg/day) and a group treated with MWCNTs+CQ (20mg/kg/day). After two-weeks of intraperitoneal (i.p.) injections, rats were subjected to the Morris water maze (MWM) test, and the long-term potentiation (LTP) and other biochemical parameters were determined. Results showed that MWCNTs could induce cognitive deficit...Continue Reading

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Citations

Sep 3, 2016·Experimental and Therapeutic Medicine·Nina V SayapinaKirill S Golokhvast
Jul 17, 2018·Scanning·Kazuo Umemura, Shizuma Sato
Apr 18, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yuexiang WangZhuo Yang
May 13, 2019·Environmental Science and Pollution Research International·Subhashree PriyadarsiniMonalisa Mishra
Oct 18, 2020·Particle and Fibre Toxicology·Xiaoli FengLongquan Shao

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