Cognitive disorders in Parkinson's disease: Confirmation of a spectrum of severity

Parkinsonism & Related Disorders
Kathy DujardinAlbert F G Leentjens

Abstract

Clinical presentation and progression of cognitive disorders in Parkinson's disease (PD) is heterogeneous. Our objective was to confirm prospectively a previous exploratory cluster analysis based on retrospective data that identified five cognitive phenotypes in PD. A model-based confirmatory cluster analysis was conducted on the results of neuropsychological tests administered in 156 PD patients from two European movement disorder centers (Lille, n = 81; Maastricht, n = 75). The number of clusters was determined on the basis of statistical criteria as well as clinical plausibility. A factorial discriminant analysis assessed the quality of the clusters' separation. A five-cluster model was statistically superior and clinically the most relevant. These clusters can be described as follows: 1) cognitively intact patients with high level of performance in all cognitive domains (25.64%), 2) cognitively intact patients slightly slower than those in cluster 1 (26.92%), 3) patients with deficits in executive functions (37.18%), 4) patients with severe deficits in all cognitive domains, particularly executive functions (3.20%), 5) patients with severe deficits in all cognitive domains, particularly working memory and recall in verbal e...Continue Reading

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Citations

Sep 22, 2016·Scientific Reports·Blake J LawrenceAndrea M Loftus
Jun 20, 2016·Revue neurologique·K DujardinUNKNOWN NS-Park network
Jan 22, 2017·Parkinsonism & Related Disorders·Nadeeka N W DissanayakaUNKNOWN ICICLE-PD study group
Jul 7, 2017·Gerontology & Geriatric Medicine·Wannipat BuatedTsutomu Fujinami
Aug 24, 2017·Acta Neurologica Scandinavica·J DupouyUNKNOWN PARKMIP group
Jul 4, 2018·Neuropsychological Rehabilitation·Daniel FellmanMatti Laine
Oct 23, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Nacim BetrouniKathy Dujardin
Nov 24, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Nacim BetrouniKathy Dujardin
Jun 15, 2020·Journal of Neurology·Dana PourzinalNadeeka N Dissanayaka
Aug 15, 2019·Network Neuroscience·Aya KabbaraMahmoud Hassan
Feb 25, 2020·Brain Communications·Hayley J MacDonaldNed Jenkinson
Feb 13, 2018·Journal of Clinical and Experimental Neuropsychology·Laura Alonso-RecioJuan Manuel Serrano
Sep 27, 2020·Parkinsonism & Related Disorders·Guillaume CareyKathy Dujardin
Nov 17, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Amée F WoltersKathy Dujardin

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