Cognitive dysfunction and symptom burden in women treated for breast cancer: a prospective behavioral and fMRI analysis

Brain Imaging and Behavior
Mi Sook JungBernadine Cimprich

Abstract

Neural dysfunction and cognitive complaints are associated with chemotherapy for breast cancer although trajectory and contributory factors remain unclear. We prospectively examined neurocognition using fMRI and self-reported cognitive, physical and psychological symptoms in women treated with adjuvant chemotherapy over one year. Patients treated with (n = 28) or without (n = 34) chemotherapy for localized breast cancer and healthy controls (n = 30) performed a Verbal Working Memory Task (VWMT) during fMRI and provided self-reports at baseline (pre-adjuvant treatment), five- (M5) and 12-months (M12). Repeated measures ANOVA and multivariable regression determined change over time and possible predictors (e.g., hemoglobin, physical symptoms, worry) of VWMT performance, fMRI activity in the frontoparietal executive network, and cognitive complaints at M12. Trajectories of change in VWMT performance for chemotherapy and healthy control groups differed significantly with the chemotherapy group performing worse at M12. Chemotherapy patients had persistently higher spatial variance (neural inefficiency) in executive network fMRI-activation than both other groups from baseline to M12. Cognitive complaints were similar among groups ove...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 17, 2001·Nursing Research·B Cimprich, D L Ronis
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jul 30, 2003·Cancer Nursing·Bernadine Cimprich, David L Ronis
Sep 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·James K NelsonEdward E Smith
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Mar 16, 2005·The Breast : Official Journal of the European Society of Mastology·V ShillingD Bloomfield
Jun 16, 2005·NeuroImage·Torben E LundOlaf B Paulson
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helen G Mar FanIan F Tannock
Feb 27, 2007·Journal of Anxiety Disorders·Roger CovinDavid J A Dozois
Aug 30, 2008·Journal of Affective Disorders·Kurt KroenkeAli H Mokdad
Nov 26, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles W GivenDavid Decker
Jul 31, 2009·Journal of Clinical and Experimental Neuropsychology·Bernadine CimprichRobert C Welsh
Dec 19, 2009·Psycho-oncology·Marleen J J PullensJan A Roukema
Mar 10, 2010·Psycho-oncology·Bernadine CimprichDavid L Ronis
Sep 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim A AhlesPeter A Kaufman
Jan 26, 2011·Cognitive, Affective & Behavioral Neuroscience·Marc G BermanJohn Jonides
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia A GanzThomas R Belin
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sabine DeprezStefan Sunaert
Dec 29, 2011·Oncology Nursing Forum·Jamie S Myers
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brenna C McDonaldAndrew J Saykin
Oct 12, 2012·Breast Cancer Research and Treatment·Patricia A Reuter-Lorenz, Bernadine Cimprich
Jan 15, 2013·Current Opinion in Supportive and Palliative Care·Lisa J Wood, Kristianna Weymann
Aug 7, 2013·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Marc G BermanBernadine Cimprich
Apr 11, 2014·International Review of Psychiatry·Michelle C JanelsinsGary R Morrow
Aug 21, 2014·Breast Cancer Research and Treatment·Mary K AskrenBernadine Cimprich
Oct 29, 2014·PloS One·Bratislav MišićMarc G Berman
Nov 28, 2014·Clinical Journal of Oncology Nursing·Diane Von AhDeborah H Allen

❮ Previous
Next ❯

Citations

Jul 21, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Paulina AndryszakPaweł Izdebski
Feb 20, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Joel B EpsteinBarbara A Murphy
Oct 17, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LangeH Castel
May 19, 2017·Journal of the National Cancer Institute·Sanne B Schagen, Jeffrey S Wefel
Mar 25, 2018·Head & Neck·Bethany Andrews RhotenSheila Hedden Ridner
May 8, 2018·Journal of Cancer Survivorship : Research and Practice·Victoria J BrayJanette L Vardy
Oct 18, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yun FengLong Jiang Zhang
Jan 16, 2019·NeuroImage. Clinical·Omid KardanMarc G Berman
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LangeH Castel
Jun 19, 2021·Oncology Nursing Forum·Yesol YangCristina C Hendrix
Jan 19, 2020·Journal of Pain and Symptom Management·Carmen KohlerMaria C Katapodi

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
dissection

Software Mentioned

SPM5
SPM8
MCFLIRT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.