Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study

Archives of Disease in Childhood
Dag SulheimMerete Glenne Øie

Abstract

To compare cognitive function in adolescents with chronic fatigue with cognitive function in healthy controls (HC). Cross-sectional study. Paediatric department at Oslo University Hospital, Norway. 120 adolescents with chronic fatigue (average age 15.4 years; range 12-18) and 39 HC (average age 15.2 years; range 12-18). The adolescents completed a neurocognitive test battery measuring processing speed, working memory, cognitive inhibition, cognitive flexibility, verbal learning and verbal memory, and questionnaires addressing demographic data, depression symptoms, anxiety traits, fatigue and sleep problems. Parents completed the Behaviour Rating Inventory of Executive Function (BRIEF), which measures the everyday executive functions of children. Adolescents with chronic fatigue had impaired cognitive function compared to HC regarding processing speed (mean difference 3.3, 95% CI 1.1 to 5.5, p=0.003), working memory (-2.4, -3.7 to -1.1, p<0.001), cognitive inhibition response time (6.2, 0.8 to 11.7, p=0.025) and verbal learning (-1.7, -3.2 to -0.3, p=0.022). The BRIEF results indicated that everyday executive functions were significantly worse in the chronic fatigue group compared to the HC (11.2, 8.2 to 14.3, p<0.001). Group di...Continue Reading

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Citations

Dec 18, 2015·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Vegard Bruun WyllerTom Eirik Mollnes
Sep 21, 2016·Journal of Clinical and Experimental Neuropsychology·Laura Anne WortingerVegard Bruun Wyller
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Feb 1, 2021·Journal of Translational Medicine·Tarjei Tørre AsprustenVegard Bruun Bratholm Wyller

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