Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA.

The Journal of Infectious Diseases
Mahalia S DesruisseauxHerbert B Tanowitz

Abstract

Cerebral malaria complicated by cognitive sequelae is a major cause of morbidity in humans infected with Plasmodium falciparum. To model cognitive function after malaria, we created a rodent model of cerebral malaria by infecting C57BL/6 mice with Plasmodium berghei strain ANKA. After 7 days, an object-recognition test of working memory revealed a significant impairment in the visual memory of infected mice. This impairment was observed in the absence of confounding effects of infection. The cognitive dysfunction correlated with hemorrhage and inflammation. Furthermore, microglial activity and morphological changes detected throughout the brains of infected mice were absent from the brains of control mice, and this correlated with the measured cognitive defects. Similar testing methods in human studies could help identify subjects at risk for an adverse cognitive outcome. This murine model should facilitate the study of adjunctive methods to ameliorate adverse neurological outcomes in cerebral malaria.

References

Nov 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·H B Gernaat
Apr 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·M V Prakash, G Stein
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·J R Rest
Jan 1, 1994·Experimental Brain Research·A Ennaceur, J P Aggleton
Jan 1, 1993·Journal of the Neurological Sciences·G Stoltenburg-DidingerP G Kremsner
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Oct 8, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D C RogersJ E Martin
Jul 28, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C PumaJ C Bizot
Mar 4, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·P A HoldingK Marsh
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
Apr 13, 2002·Neuropsychology·F CateriniO H Tumbull
Oct 24, 2002·Journal of Developmental and Behavioral Pediatrics : JDBP·Michael J Boivin
Nov 7, 2002·Archives of General Psychiatry·Glen M DonigerDaniel C Javitt
Dec 11, 2002·Journal of the American Geriatrics Society·Craig J WilsonHarvey J Cohen
Jul 16, 2003·Acta Neurologica Scandinavica·S LaatuJ O Rinne
Sep 12, 2003·Trends in Immunology·Nicholas H Hunt, Georges E Grau
Jun 9, 2004·Neurobiology of Learning and Memory·Rebecca S HammondRobert W Stackman
Jan 19, 2005·Tropical Medicine & International Health : TM & IH·Julie A CarterCharles R J C Newton
Feb 25, 2005·The Annals of Pharmacotherapy·Denise S TelgtRobert W Sauerwein
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J A CarterC R J C Newton
May 27, 2005·Parasitology Research·Richard P KennanHerbert B Tanowitz
Aug 25, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Deepika FernandoRajitha Wickremasinghe
Oct 1, 2005·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·M J Eacott, E A Gaffan
Nov 22, 2005·Lancet Neurology·Richard IdroCharles R J C Newton
Dec 20, 2005·Developmental Medicine and Child Neurology·Julie A CarterCharles R J C Newton
Mar 24, 2006·Tropical Medicine & International Health : TM & IH·Michael KiharaCharles R J C Newton
Apr 8, 2006·Neuropathology and Applied Neurobiology·P LacknerE Schmutzhard
Aug 1, 2006·Neurologic Clinics·Robert Dantzer
Sep 20, 2006·Journal of Neurochemistry·Rebecca GriffinMarina A Lynch
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathan L SparkmanRodney W Johnson
Nov 16, 2006·Glia·Alain BessisAnne Roumier
Jan 17, 2007·Pediatrics·Michael J BoivinChandy C John

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Citations

Dec 22, 2010·Malaria Journal·Sumadhya D FernandoSenaka Rajapakse
Oct 1, 2010·Journal of Neuroparasitology·Mahalia S DesruisseauxDavid C Spray
Aug 25, 2015·International Journal for Parasitology·Dominique F LeitnerJames R Connor
Dec 7, 2010·Neuroscience Letters·Nina K PopovaTamara G Amstislavskaya
Sep 4, 2010·Pharmacology & Therapeutics·Ian A ClarkBryce Vissel
Jan 23, 2010·The American Journal of Pathology·Mahalia S DesruisseauxLinnie M Golightly
May 2, 2014·Life Sciences·Brandi D FreemanMahalia S Desruisseaux
Oct 2, 2012·The American Journal of Pathology·Henry J ShikaniMahalia S Desruisseaux
Mar 17, 2015·PloS One·Norinne Lacerda-QueirozAntonio Lucio Teixeira
Apr 28, 2017·PLoS Pathogens·Flora ReverchonValérie F J Quesniaux
Mar 21, 2018·Parasites & Vectors·Luciana Pereira de SousaCláudio Tadeu Daniel-Ribeiro
Jul 25, 2020·Malaria Journal·Nicoline SchiessMonique F Stins
Dec 13, 2018·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Ruchika Saroa, Upma Bagai
Nov 16, 2010·Expert Review of Anti-infective Therapy·Guy A Zimmerman, Hugo Castro-Faria-Neto
Oct 27, 2020·Frontiers in Cellular and Infection Microbiology·Brenda Jaqueline de Azevedo AtaideKaren Renata Herculano Matos Oliveira
Jul 23, 2021·Scientific Reports·Luciana Pereira de SousaCláudio Tadeu Daniel-Ribeiro

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