Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI

Brain : a Journal of Neurology
David J WerringH Rolf Jäger

Abstract

Gradient echo T2*-weighted MRI has high sensitivity in detecting cerebral microbleeds, which appear as small dot-like hypointense lesions. Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic small vessel disease, and have generated interest as a marker of bleeding-prone microangiopathy. Microbleeds have generally been considered to be clinically silent; however, since they are located in widespread cortical and basal ganglia regions and are histologically characterized by tissue damage, we hypothesized that they would cause cognitive dysfunction. We therefore studied patients with microbleeds (n = 25) and a non-microbleed control group (n = 30) matched for age, gender and intelligence quotient. To avoid the confounding effects of coexisting cerebrovascular disease, the groups were also matched for the extent of MRI-visible white matter changes of presumed ischaemic origin, location of cortical strokes, and for the proportion of patients with different stroke subtypes (including lacunar stroke). A battery of neuropsychological tests was used to assess current intellectual function, verbal and visual memory, naming and perceptual skills, speed and attention and executive ...Continue Reading

Citations

Aug 7, 2012·Journal of Neurology·Robert HurfordDavid J Werring
Apr 12, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·W K TangK S Wong
Sep 23, 2006·Nature Clinical Practice. Neurology·Ola A Selnes, Harry V Vinters
Jan 25, 2011·Brain : a Journal of Neurology·Charlotte Cordonnier, Wiesje M van der Flier
May 31, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Jacques De ReuckFlorence Pasquier
Aug 16, 2006·Neuro-degenerative Diseases·Alireza AtriSteven M Greenberg
May 13, 2006·Cerebrovascular Diseases·Luís F MaiaManuel Correia
Aug 5, 2006·Cerebrovascular Diseases·Bruce OvbiageleDavid S Liebeskind
May 16, 2009·Stroke; a Journal of Cerebral Circulation·Steven M GreenbergEric E Smith
Dec 16, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Beom Joon KimByung-Woo Yoon
Nov 10, 2012·Neurology International·Ryuji SakakibaraTatsuya Yamamoto
Oct 22, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jin-Biao ZhangFang Li
Jul 6, 2014·Alzheimer's Research & Therapy·Sergi Martinez-RamirezAnand Viswanathan
Nov 20, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Robert HurfordDavid J Werring
Mar 13, 2014·American Journal of Hypertension·Miesje van DoorenRobert J van Oostenbrugge
Sep 4, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shinichiro MaeshimaNorio Tanahashi
Sep 2, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Junpei NagasawaKen Ikeda
Nov 13, 2008·AJNR. American Journal of Neuroradiology·R N Kaveer NandigamB C Dickerson
May 7, 2011·AJNR. American Journal of Neuroradiology·Mandy M A ConijnJeroen Hendrikse
May 26, 2012·AJNR. American Journal of Neuroradiology·L SabaM Piga
Sep 10, 2013·Revue neurologique·K MuraoCharlotte Cordonnier
Nov 23, 2011·Cerebrovascular Diseases·Ashkan ShoamaneshO Benavente
Aug 14, 2009·Expert Review of Neurotherapeutics·Marta Grau-Olivares, Adrià Arboix
Oct 16, 2015·Journal of Stroke·Eun-Jae LeeSteven Warach
Dec 22, 2015·Biochimica Et Biophysica Acta·Gargi BanerjeeDavid J Werring
May 3, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kazuo YamashiroTakao Urabe
Aug 5, 2015·Intelligence·Stuart J RitchieIan J Deary
Mar 17, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Pierre Yves GarciaOlivier Godefroy
Jul 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Reisa A SperlingRachel J Schindler
Oct 23, 2010·Journal of the Neurological Sciences·Jacques De ReuckClaude-Alain Maurage
Sep 21, 2010·Journal of the Neurological Sciences·Margherita Cavalieri, Reinhold Schmidt
Sep 21, 2010·Journal of the Neurological Sciences·David J WerringLisa Cipolotti
Sep 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroo IchikawaMitsuru Kawamura
Jun 29, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuki TakashimaHiroshi Yao
Feb 27, 2010·La Presse médicale·Philippe Goas, Serge Timsit
Apr 13, 2010·Clinical Radiology·Simone M GregoireH Rolf Jäger
May 7, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yael D ReijmerSteven M Greenberg
Dec 2, 2008·Behavioural Brain Research·Crystal L MacLellanDale Corbett
Oct 18, 2008·Neurobiology of Aging·Anand ViswanathanHugues Chabriat
Sep 2, 2008·Revue neurologique·Charlotte Cordonnier
Jun 24, 2008·Academic Radiology·Christoph StehlingWalter Heindel
Jun 6, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Valeria KebetsDavid J Werring
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Jens Fiehler
Jan 6, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Bhavini Patel, Hugh S Markus
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Chris MoranVelandai K Srikanth
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Wai Kwong TangKa Sing Wong
Aug 28, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Jason MackeyChelsea S Kidwell
Dec 24, 2005·Annals of Neurology·Marjo S van der KnaapPeter Heutink
Jul 5, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·David J Werring
Jun 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·Mandy M A ConijnJeroen Hendrikse
Jan 13, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Caroline V FulkersonJonathan M Levine
Sep 25, 2010·Annals of Neurology·Gregory A DierksenSteven M Greenberg
Nov 22, 2011·NMR in Biomedicine·Ewald MoserSiegfried Trattnig
Mar 31, 2016·International Journal of Radiation Oncology, Biology, Physics·Qingyu ShenYamei Tang
Oct 15, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Ryuji SakakibaraMasashi Yano
May 18, 2013·Neuropathology and Applied Neurobiology·B M JanawayMRC Cognitive Function and Ageing Neuropathology Study
Dec 10, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K ShibazakiK Sakai
May 26, 2009·Brain Research·Richard HartmanJohn H Zhang
Dec 18, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yusuke YakushijiHideo Hara
Oct 9, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Matthew S Schrag, David M Greer
Feb 3, 2007·Archives of Physical Medicine and Rehabilitation·Sandra ZinnH Scott Swartzwelder
Aug 1, 2015·AJNR. American Journal of Neuroradiology·G C ChiangAlzheimer's Disease Neuroimaging Initiative
Jun 13, 2014·Journal of Neurology·Jee Hyun HamPhil Hyu Lee
Jun 11, 2015·Journal of Stroke·Beom Joon Kim, Seung-Hoon Lee
Apr 9, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jennifer L WhitwellKeith A Josephs
Apr 26, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yumiko NakanoKoji Abe
Apr 25, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Adnan I QureshiM Fareed K Suri
Jul 25, 2012·Experimental Gerontology·Wiesje M van der Flier, Charlotte Cordonnier
Apr 30, 2013·Neurobiology of Aging·Anouk G W van NordenFrank-Erik de Leeuw
May 12, 2012·Journal of the Neurological Sciences·Amos D KorczynLea T Grinberg
Jun 22, 2012·Journal of the Neurological Sciences·Andreas Charidimou, David J Werring
Jun 26, 2012·Journal of the Neurological Sciences·Stephan SeilerReinhold Schmidt
Apr 10, 2014·Frontiers in Aging Neuroscience·Fred Rincon, Clinton B Wright
Jul 6, 2014·BioMed Research International·Meng Yue TangXiao Hua Huang
Jan 10, 2012·QJM : Monthly Journal of the Association of Physicians·P KakarD Ames
Jun 2, 2016·Annals of Nuclear Medicine·Tetsuya HashimotoKazunori Toyoda
Sep 24, 2014·PloS One·Ping HuaSong-ran Yang
Mar 5, 2016·Postgraduate Medical Journal·Guendalina Bonifacio, Giovanna Zamboni
Sep 23, 2008·Handbook of Clinical Neurology·Bo Norrving
Mar 30, 2017·Neurobiology of Aging·José R RomeroSudha Seshadri
Feb 9, 2017·Journal of Hypertension·Renske UiterwijkRobert J van Oostenbrugge
Apr 10, 2013·The Journal of International Medical Research·Min ZhangWusheng Zhu
Nov 15, 2016·The International Journal of Neuroscience·Zhenjie TengPeiyuan Lv
Feb 20, 2014·Journal of Geriatric Psychiatry and Neurology·W K TangK S Wong
Oct 28, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Leka SivakumarKen Butcher
Jan 1, 2012·JRSM Cardiovascular Disease·Puneet KakarDavid J Werring
Mar 21, 2018·Radiology·Sven HallerFrederik Barkhof
Nov 24, 2017·Scientific Reports·Young Kyoung JangSang Won Seo
Mar 14, 2018·Neural Plasticity·Annalisa Scimemi
Mar 21, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariCalin I Prodan
Jul 13, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Lara A BoydSteven C Cramer
Jan 11, 2014·American Journal of Alzheimer's Disease and Other Dementias·Javier OlazaránJuan Alvarez-Linera
May 15, 2012·Stroke; a Journal of Cerebral Circulation·Yusuke YakushijiHideo Hara
May 9, 2013·Stroke; a Journal of Cerebral Circulation·Ralph L SaccoCouncil on Nutrition, Physical Activity and Metabolism
Feb 6, 2017·Circulation Research·Martin Dichgans, Didier Leys
Dec 24, 2005·Stroke; a Journal of Cerebral Circulation·Guy M McKhannOla A Selnes
Jan 7, 2006·Stroke; a Journal of Cerebral Circulation·Anand Viswanathan, Hugues Chabriat
Aug 19, 2006·Stroke; a Journal of Cerebral Circulation·Vladimir HachinskiGabrielle G Leblanc
Aug 9, 2008·Stroke; a Journal of Cerebral Circulation·Yusuke YakushijiYasuo Kuroda
May 14, 2011·Stroke; a Journal of Cerebral Circulation·Jeroen D C GoosMike P Wattjes
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Karlijn F de LaatFrank-Erik de Leeuw
Feb 27, 2007·Stroke; a Journal of Cerebral Circulation·Robin LemmensVincent Thijs
Jun 25, 2016·Stroke; a Journal of Cerebral Circulation·Nevicia F CaseEric E Smith
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Sang Won SeoDuk L Na
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Julie A Schneider
Feb 21, 2009·Stroke; a Journal of Cerebral Circulation·Salka S StaekenborgWiesje M van der Flier
Dec 26, 2008·Stroke; a Journal of Cerebral Circulation·Wouter J P HennemanWiesje M van der Flier
Nov 7, 2009·Stroke; a Journal of Cerebral Circulation·Simone M GregoireDavid J Werring
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Michael K LiemSaskia A J Lesnik Oberstein
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Bhavini PatelHugh S Markus
Aug 8, 2009·Stroke; a Journal of Cerebral Circulation·Julie StaalsJan Lodder
Sep 19, 2009·Stroke; a Journal of Cerebral Circulation·Jeroen D C GoosWiesje M van der Flier
Jul 16, 2011·Stroke; a Journal of Cerebral Circulation·W K TangK S Wong
Mar 14, 2013·Stroke; a Journal of Cerebral Circulation·Simone M GregoireDavid J Werring
Feb 15, 2019·Journal of Neurology·Nicolas ChristFelix Fluri
Mar 9, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Gabor A FulopZoltan Ungvari
Jun 13, 2012·Rinshō shinkeigaku = Clinical neurology·Toshiki Mizuno
Dec 1, 2012·Rinshō shinkeigaku = Clinical neurology·Yusuke Yakushiji, Hideo Hara
Jun 21, 2019·Current Neurology and Neuroscience Reports·Solene Moulin, Charlotte Cordonnier
Mar 1, 2019·Neurology·Brittany S PassiakAngela L Jefferson
Sep 24, 2019·Clinical and Experimental Hypertension : CHE·Lingchun LyuWei Mao
May 21, 2019·Therapeutic Advances in Neurological Disorders·Szu-Ju ChenJiann-Shing Jeng
Jul 29, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·Emre KumralMehmet Orman
Jun 3, 2020·Alzheimer Disease and Associated Disorders·Chathuri YatawaraNagaendran Kandiah
Oct 4, 2018·Medicine·Pahn Kyu ChoiHyun Goo Kang
Sep 11, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Jun YoshidaKuniaki Ogasawara
Dec 25, 2018·Stroke; a Journal of Cerebral Circulation·Kang-Ho ChoiKi-Hyun Cho
Jun 13, 2020·Frontiers in Veterinary Science·Susan A ArnoldFranklin D West
May 29, 2018·Brain Imaging and Behavior·Matt ParadisePerminder S Sachdev
Dec 23, 2018·Stroke; a Journal of Cerebral Circulation·Nikil PatelEmma M L Chung
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Laurent PuyGRECogVASC Study Group
Mar 17, 2019·International Journal of Molecular Sciences·Maria Del C Valdés HernándezJoanna M Wardlaw
Nov 8, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Rihan WuXueyuan Liu
Nov 20, 2016·Nature Reviews. Neurology·Yusuke Yakushiji, David J Werring
Oct 1, 2009·Dementia & Neuropsychologia·Leonel Tadao TakadaClaudia da Costa Leite
Dec 20, 2018·Neurology. Clinical Practice·Hannah BreitSayona John
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Lin LiAlzheimer’s Disease Neuroimaging Initiative
Jan 9, 2019·Frontiers in Neuroscience·Maria Daglas, Paul A Adlard
Oct 5, 2020·GeroScience·Luca TothPeter Toth
Oct 4, 2020·Scientific Reports·Masahiro NakamoriHirofumi Maruyama

Related Concepts

Mental Concentration
Cerebral Hemorrhage
Cerebrovascular Occlusion
Overinclusion
Mental Tests
Memory
Memory for Designs Test
Retrospective Studies
Visual Perception
Echo-Planar MR Tomography

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.