Cognitive effects of adjunctive N-acetyl cysteine in psychosis

Psychological Medicine
Marta Rapado-CastroOlivia Dean

Abstract

Cognitive deficits are predictors of functional outcome in patients with psychosis. While conventional antipsychotics are relatively effective on positive symptoms, their impact on negative and cognitive symptoms is limited. Recent studies have established a link between oxidative stress and neurocognitive deficits in psychosis. N-acetylcysteine (NAC), a glutathione precursor with glutamatergic properties, has shown efficacy on negative symptoms and functioning in patients with schizophrenia and bipolar disorder, respectively. However, there are few evidence-based approaches for managing cognitive impairment in psychosis. The present study aims to examine the cognitive effects of adjunctive NAC treatment in a pooled subgroup of participants with psychosis who completed neuropsychological assessment in two trials of both schizophrenia and bipolar disorder. A sample of 58 participants were randomized in a double fashion to receive 2 g/day of NAC (n = 27) or placebo (n = 31) for 24 weeks. Attention, working memory and executive function domains were assessed. Differences between cognitive performance at baseline and end point were examined using Wilcoxon's test. The Mann-Whitney test was used to examine the differences between the...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Sep 1, 1992·The American Journal of Psychiatry·H H GoldmanT R Lave
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
May 1, 1995·Psychosomatics·R C Hall
Jul 23, 1998·Neuropsychology·R W Heinrichs, K K Zakzanis
Dec 11, 2002·Journal of the American Geriatrics Society·Craig J WilsonHarvey J Cohen
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Nov 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Celia J A MorganH Valerie Curran
Feb 15, 2005·BMC Medical Genetics·Daniel R Hanson, Irving I Gottesman
Sep 27, 2005·Schizophrenia Research·Lydia KrabbendamAndré Aleman
Mar 2, 2006·Psychotherapy and Psychosomatics·Claire DabanEduard Vieta
Jul 10, 2007·Schizophrenia Bulletin·John A Gray, Bryan L Roth
Sep 8, 2007·BMC Psychiatry·Peter SaetreElena Jazin
Oct 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Ralph E HoffmanThomas H McGlashan
Nov 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzie LavoieKim Q Do
Jan 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Janet B W Williams, Kenneth A Kobak
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
Jun 10, 2008·Trends in Pharmacological Sciences·Michael BerkAshley I Bush
Jul 16, 2008·Cognitive Neuropsychiatry·Stéphane PotvinEmmanuel Stip
Aug 16, 2008·Brain Research Reviews·Handan Gunduz-Bruce
May 6, 2009·Neuropsychology·Raquelle I Mesholam-GatelyLarry J Seidman
Aug 25, 2009·Lancet·Jim van Os, Shitij Kapur
Sep 8, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Mahmut BulutAlican Dalkilic
Sep 22, 2009·European Archives of Psychiatry and Clinical Neuroscience·Arantzazu ZabalaI Bombin
Dec 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Emre BoraChristos Pantelis
Jan 6, 2010·The American Journal of Psychiatry·Abraham ReichenbergTerrie E Moffitt
Jul 14, 2010·Neuroscience and Biobehavioral Reviews·Anne-Kathrin J FettLydia Krabbendam
Sep 28, 2010·European Journal of Pharmacology·Kwok Ho Christopher ChoyMaarten van den Buuse
Dec 2, 2010·Journal of Psychiatry & Neuroscience : JPN·Olivia M DeanMichael Berk
Jul 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David-Marian OtteAndreas Zimmer
Oct 26, 2011·Schizophrenia Research·Madiha ShaikhElvira Bramon
Nov 1, 2011·Biological Psychiatry·Handan Gunduz-BruceDaniel H Mathalon
Feb 2, 2012·Nature Reviews. Drug Discovery·Mark J MillanLarry J Young
Mar 27, 2012·Schizophrenia Research·Mónica Martínez-CengotitabengoaAna González-Pinto
Jun 6, 2012·Archives of General Psychiatry·Paolo Fusar-PoliStefan Borgwardt
Sep 19, 2012·Psychiatry Research·Itxaso González-OrtegaAna González-Pinto
Oct 17, 2012·Psychiatry and Clinical Neurosciences·Olivia DeanMichael Berk
Nov 28, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seetal DoddMichael Berk
Feb 2, 2013·Trends in Pharmacological Sciences·Michael BerkOlivia Dean
Apr 27, 2013·Biochimica Et Biophysica Acta·Yuval SamuniMichael Berk
Jul 17, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Naomi R DriesenJohn H Krystal
Jul 19, 2013·Clinical Neuropharmacology·Mary J HolmayPaul J Tuite
Feb 4, 2014·Progress in Molecular Biology and Translational Science·P J BanksZ I Bashir
Apr 29, 2014·Schizophrenia Research·Mónica Martínez-CengotitabengoaAna González-Pinto
May 8, 2014·The Australian and New Zealand Journal of Psychiatry·Justin DavisMichael Berk
May 28, 2014·Journal of Psychiatric Research·Isabelle E BauerJair C Soares
Jun 13, 2014·The Journal of Clinical Psychiatry·Adriane R RosaFlávio Kapczinski
Jul 23, 2014·Molecular Psychiatry·René S Kahn, I E Sommer
Oct 16, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta Rapado-CastroOlivia Dean
Nov 27, 2014·The Australian and New Zealand Journal of Psychiatry·Minji BangSuk Kyoon An
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Ashwini RajasekaranMonojit Debnath
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Monojit DebnathMichael Berk
Jan 15, 2015·Journal of Psychopharmacology·Oliver HowesJames Stone
Feb 11, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anabel Martinez-Aran, Eduard Vieta
Apr 29, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Dohoon KimSeung-Hee Won
Apr 29, 2015·International Journal of Bipolar Disorders·Rothanthi DaglasMichael Berk
May 11, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Annabel VreekerRené S Kahn
May 11, 2015·Neuroscience and Biobehavioral Reviews·DeepmalaRichard Frye

Citations

Jun 1, 2016·Drug and Alcohol Review·Rebecca McKetinMichael Berk
Feb 12, 2017·The Lancet. Psychiatry·Michael Berk, Lesley Berk
Apr 26, 2019·Expert Review of Neurotherapeutics·Matthew J KnightBernhard T Baune
Mar 9, 2018·Nature Reviews. Disease Primers·Eduard VietaIria Grande
Jul 10, 2019·The International Journal of Neuropsychopharmacology·Emeline MullierPatric Hagmann
Apr 28, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peiyan Ni, Sangmi Chung
Mar 20, 2020·Current Pharmaceutical Design·Vicent Balanzá-MartínezPilar López-García
Feb 17, 2019·The Journal of Nutrition·Uzoma S IkonneNathalie Sumien
May 28, 2019·The Mental Health Clinician·Robert J WillbornMatthew A Fuller
May 1, 2019·Antioxidants·Špela ŠalamonIrina Milisav
Dec 13, 2019·The Australian and New Zealand Journal of Psychiatry·Caitlin Ob YollandDan Siskind
Jul 9, 2020·Journal of Clinical Psychopharmacology·Antonio BrunoMaria Rosaria Anna Muscatello
Jan 23, 2020·Scientific Reports·William R ReayMurray J Cairns
Jan 29, 2019·Early Intervention in Psychiatry·Oliver D RobertsonSeetal Dodd
Oct 22, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A S PyatoykinaG E Mazo
Nov 16, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M IoannouR A Schoevers
Jan 28, 2021·Antioxidants·Tonali Blanco Blanco AyalaVerónica Pérez de la Pérez de la Cruz
Feb 11, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D A MaasG J M Martens
Feb 9, 2021·Oxidative Medicine and Cellular Longevity·Evgeny A ErmakovLiudmila P Smirnova
Mar 14, 2020·Pharmacology & Therapeutics·Andrea Carlo RossettiRaffaella Molteni

Related Concepts

Acetylcysteine, (DL)-Isomer
Mental Concentration
Manic Disorder
Immediate Recall
Schizophreniform Disorders
Schizophrenia
Free Radical Scavengers
Executive Function
Mild Cognitive Disorder
Acetylcysteine

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here