Cognitive Effects of Bifrontal Versus Right Unilateral Electroconvulsive Therapy in the Treatment of Major Depression in Elderly Patients: A Randomized, Controlled Trial

The Journal of ECT
Gro Strømnes DybedalLars Tanum

Abstract

Bifrontal (BF) electrode placement has been explored to refine the electroconvulsive therapy (ECT) technique. No previous study has compared the cognitive effects of BF versus right unilateral (RUL) ECT by only including the subgroup that is most likely to receive it: elderly patients with major depression. Nondemented patients (n = 65) with major depression, aged 60 to 85 years, were randomly allocated to BF ECT and RUL formula-based ECT. Cognitive function was assessed at baseline (T1), within 1 week after a course of ECT (T2), and 3 months after T2 (T3). Six neuropsychological test measures of memory, 5 of executive function, and 3 of information-processing speed were administered. According to linear mixed models, there were no significant differences between the BF and RUL groups at any time. The retrograde memory score for public facts declined more for the RUL group (P < 0.001) than the BF group (P = 0.005) from baseline to the first retest and remained stable for both groups from T2 to T3. A rapid improvement in selective attention was observed in the RUL group from T1 to T2, but the scores remained stable from T2 to T3 (P < 0.001). This measure remained stable in the BF group from T1 to T3. Our findings indicate that t...Continue Reading

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Citations

Nov 23, 2017·The Journal of ECT·Lucie KalisovaJiri Raboch
Jul 3, 2020·Indian Journal of Psychological Medicine·Jagadisha ThirthalliGirish Kunigiri
Nov 11, 2019·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Sarah H LisanbyUNKNOWN CORE/PRIDE Work Group
Apr 6, 2021·Journal of Caring Sciences·Saeed Alinejad MachianiSakineh Goljarian
Jun 3, 2021·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Sarah H LisanbyUNKNOWN Prolonging Remission in Depressed Elderly (PRIDE) Work Group
Aug 30, 2016·Revista de psiquiatrí́a y salud mental·Francisco Javier Sanz-Fuentenebro

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