Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Joel S PeckDeborah Goebert

Abstract

Given that circadian rhythm disruption is associated with impairments in cognitive performance similar to those found in age-related cognitive decline, the authors investigated whether exogenous melatonin administration would improve cognitive functioning in healthy elderly subjects. This double-blind, placebo-controlled pilot study assigned 26 healthy elderly subjects to receive either melatonin 1 mg or placebo nightly for 4 weeks. Participants completed a sleep questionnaire and a battery of cognitive tests at baseline and at 4 weeks. Melatonin administration improved reported morning "restedness" and sleep latency after nocturnal awakening, and also improved scores on the California Verbal Learning Test-interference subtest. Melatonin administration at a dose of 1 mg nightly may be effective in improving certain aspects of cognitive functioning and subjective reports of sleep quality in elderly subjects. It may prove to be a useful therapeutic agent in the treatment of age-related cognitive decline.

Citations

Jun 2, 2011·International Journal of Alzheimer's Disease·Venkatramanujam SrinivasanDaniel P Cardinali
Jun 25, 2013·Maturitas·Antonio González-SarríasJuan Carlos Espín
Apr 20, 2010·Pharmacology & Therapeutics·Regina P MarkusZulma S Ferreira
Aug 29, 2014·Human Psychopharmacology·Paul S FosterValeria Drago
Jan 5, 2011·International Journal of Alzheimer's Disease·Venkatramanujam SrinivasanDaniel P Cardinali
Apr 12, 2016·Journal of Pineal Research·Agorastos Agorastos, Astrid C E Linthorst
Jan 27, 2015·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Michael K Scullin, Donald L Bliwise
Jan 1, 2014·Antioxidants·Daniel P CardinaliLuis I Brusco
Jan 27, 2006·The Cochrane Database of Systematic Reviews·S L JansenD G Morgan
Sep 23, 2008·Harvard Review of Psychiatry·Carl Salzman
May 3, 2011·Journal of Women & Aging·Francine ConwayAmandia Speakes-Lewis
Aug 6, 2019·Frontiers in Endocrinology·Daniel P Cardinali

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Immunity & Ageing : I & a
V SrinivasanS C Miller
Journal of Alzheimer's Disease : JAD
John Xi Chen, Shirley Shidu Yan
Toxicology in Vitro : an International Journal Published in Association with BIBRA
F LuchettiE Falcieri
© 2022 Meta ULC. All rights reserved