Cognitive effects of memantine in postmenopausal women at risk of dementia: a pilot study

Acta Neurologica Scandinavica
T E WroolieN L Rasgon

Abstract

To determine the effects of memantine on cognition in a normal population of postmenopausal women with putative risk factors for Alzheimer's disease (AD) using a built-in control for the genetic risk factor for AD (apoE-epsilon4 status). A prospective, open-label, 6-month pilot medication trial with memantine and follow-up after discontinuance conducted at the Center for Neuroscience in Women's Health, Stanford University School of Medicine. Neuropsychological data were collected on 22 community-dwelling postmenopausal women (11 apoE-epsilon4 carriers and 11 apoE-epsilon4 non-carriers) with at least one putative risk factor for AD. ApoE-epsilon4 status was not a significant predictor of change in neuropsychological performance. Changes associated with memantine treatment for entire sample included significant declines in some variables associated with verbal learning and memory that improved upon medication withdrawal. A positive medication effect was noted with executive functions and possibly category fluency. Trend-level improvements were seen in motor dexterity of the non-dominant hand and maintained even after drug discontinuance. Treatment with memantine appeared to have differential effects on cognitive performance in a ...Continue Reading

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Citations

Apr 12, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Li-Jing JiaRui-Sheng Duan
Oct 12, 2015·Drug and Alcohol Dependence·Gerardo GonzalezMonika Kolodziej
Aug 4, 2015·Neurobiology of Learning and Memory·Michael GuidiThomas C Foster
Dec 20, 2017·Journal of Alzheimer's Disease : JAD·Jaume FolchAntoni Camins

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