Cognitive effects of rhythmic auditory stimulation in Parkinson's disease: A P300 study

Brain Research
Juan LeiMaren Schmidt-Kassow

Abstract

Rhythmic auditory stimulation (RAS) may compensate dysfunctions of the basal ganglia (BG), involved with intrinsic evaluation of temporal intervals and action initiation or continuation. In the cognitive domain, RAS containing periodically presented tones facilitates young healthy participants' attention allocation to anticipated time points, indicated by better performance and larger P300 amplitudes to periodic compared to random stimuli. Additionally, active auditory-motor synchronization (AMS) leads to a more precise temporal encoding of stimuli via embodied timing encoding than stimulus presentation adapted to the participants' actual movements. Here we investigated the effect of RAS and AMS in Parkinson's disease (PD). 23 PD patients and 23 healthy age-matched controls underwent an auditory oddball task. We manipulated the timing (periodic/random/adaptive) and setting (pedaling/sitting still) of stimulation. While patients elicited a general timing effect, i.e., larger P300 amplitudes for periodic versus random tones for both, sitting and pedaling conditions, controls showed a timing effect only for the sitting but not for the pedaling condition. However, a correlation between P300 amplitudes and motor variability in the p...Continue Reading

Citations

Jul 28, 2020·International Journal of Environmental Research and Public Health·Chao FangQun Fang
Sep 13, 2020·International Journal of Neural Systems·Manuel GrañaXavier Garmendia
Feb 11, 2021·Healthcare·Katarzyna Nowakowska-LipiecAndrzej W Mitas

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