PMID: 8965780Jan 1, 1996Paper

Cognitive effects of subclinical EEG discharges

Neurophysiologie clinique = Clinical neurophysiology
C D Binnie

Abstract

Many patients with epilepsy display cognitive deficits and consequent psychosocial dysfunction. Of the various biological factors contributing to these problems, the most distinctive is the momentary disruption of psychological function by subclinical EEG discharges. This is demonstrable in 50% of subjects with subclinical epileptiform activity performing a suitable task under EEG control. Transitory cognitive impairment (TCI) can often be detected during even brief focal discharges, including single spikes. The effects are material specific: right-sided discharges are more likely to affect verbal functions, whereas the left-sided produce more deficits demonstrable by non-verbal tasks. Monitoring of children during neuropsychological or educational testing shows that subclinical discharges can selectively impair performance of specific subtests, giving abnormal test profiles, and lead to errors in reading. The impact of such transitory cognitive impairment on psychosocial function in daily life is uncertain. If TCI produced significant disability, anti-epileptic drugs could improve cognition by suppressing EEG discharges, provided that any benefits were not outweighed by sedation. The author has reported a randomised, double-bl...Continue Reading

References

Dec 1, 1978·Epilepsia·C B Dodrill
Apr 1, 1988·Electroencephalography and Clinical Neurophysiology·D A Shewmon, R J Erwin
Mar 1, 1988·Epilepsy Research·D G Kasteleijn-Nolst TrenitéM Van Raaij
Mar 1, 1988·Epilepsy Research·B M SiebelinkD G Kasteleijn-Nolst Trenité
Mar 1, 1973·Electroencephalography and Clinical Neurophysiology·R J Porter, J K Penry
Mar 1, 1984·Brain : a Journal of Neurology·J H AartsA J Wilkins
Oct 1, 1980·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·S J Hutt, S Gilbert
Sep 1, 1957·A.M.A. Archives of Neurology and Psychiatry·K A KOOI, H B HOVEY
Oct 1, 1960·Journal of Consulting Psychology·O A PARSONS, D E KEMP
Apr 1, 1964·Electroencephalography and Clinical Neurophysiology·R A DAVIDOFF, L C JOHNSON
Feb 1, 1962·Archives of General Psychiatry·A JUS, K JUS

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Citations

Oct 13, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Heather Angus-Leppan
Mar 6, 2010·Psychology & Health·Laura Smart RichmanMark Bauer

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