Cognitive, emotional and social phenotyping of mice in an observer-independent setting

Neurobiology of Learning and Memory
Ekrem DereHannelore Ehrenreich

Abstract

Based on the intellicage paradigm, we have developed a novel cognitive, emotional and social phenotyping battery that permits comprehensive standardized behavioral characterization of mice in an experimenter-independent social setting. Evaluation of this battery in a large number of male and female C57BL/6 wildtype mice, tested in >20 independent cohorts, revealed high reproducibility of the behavioral readouts and may serve as future reference tool. We noticed robust sex-specific differences in general activity, cognitive and emotional behavior, but not regarding preference for social pheromones. Specifically, female mice revealed higher activity, decreased sucrose preference, impaired reversal and place-time-reward learning. Furthermore, female mice reacted more sensitively than males to reward-withdrawal showing a negative emotional contrast/Crespi-effect. In a series of validation experiments, we tested mice with different pathologies, including neuroligin-3 deficient mice (male Nlgn3y/- and female Nlgn3+/-) for autistic behavior, oligodendrocyte-specific erythropoietin receptor knockout (oEpoR-/-) mice for cognitive impairment, as well as mouse models of renal failure (unilateral ureteral obstruction and 5/6 nephrectomy) a...Continue Reading

Citations

Aug 28, 2020·Reviews in the Neurosciences·Dorothea DereEkrem Dere
Jun 3, 2021·International Journal of Molecular Sciences·Christian StetterChristiane Albert-Weißenberger
Jun 29, 2021·Frontiers in Behavioral Neuroscience·Alican CaglayanYork Winter
Aug 1, 2021·Molecular Psychiatry·Justus B H WilkeHannelore Ehrenreich
Aug 6, 2019·Neuroscience and Biobehavioral Reviews·Dorothea DereEkrem Dere

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