Cognitive enhancement in old dogs from dietary supplementation with a nutrient blend containing arginine, antioxidants, B vitamins and fish oil

The British Journal of Nutrition
Yuanlong PanNortan W Milgram

Abstract

This study focused on the hypothesis that cognitive decline in aged dogs could be attenuated by dietary supplementation with a nutrient blend consisting of antioxidants, B vitamins, fish oil and l-arginine, referred to hereafter as the Brain Protection Blend (BPB). Baseline cognitive assessment before the start of treatment was used to establish cognitively equivalent control (10·464+2·33 kg) and treatment (12·118+3·386 kg) groups of aged dogs between 9·1 and 11·5 years of age and with body condition score of 5. After an initial wash-in period, all dogs were tested over a 6-month period on cognitive test protocols that assessed four phases of a landmark discrimination learning protocol, which assessed a spatial learning skill based on utilisation of external cues, and egocentric discrimination task, which assessed spatial learning based on internal body-centred cues. The BPB-supplemented group showed significantly better performance than the controls on the landmark 1 (P=0·0446) discrimination learning tasks, and on two egocentric discrimination reversal learning tasks (P=0·005 and P=0·01, respectively). The groups did not differ significantly (P>0·10) on the landmark zero discrimination task and the egocentric discrimination l...Continue Reading

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Citations

Nov 16, 2019·Journal of the American Veterinary Medical Association·Kimberly A May, Dorothy P Laflamme
Jul 1, 2020·Animals : an Open Access Journal From MDPI·Petra ČernáDanièlle A Gunn-Moore
Mar 29, 2021·The Veterinary Clinics of North America. Small Animal Practice·Valarie V Tynes, Gary M Landsberg
Sep 9, 2021·Journal of Animal Physiology and Animal Nutrition·Jirayu TanprasertsukJustin Shmalberg

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