Cognitive Enhancement Therapy Improves Frontolimbic Regulation of Emotion in Alcohol and/or Cannabis Misusing Schizophrenia: A Preliminary Study

Frontiers in Psychiatry
Jessica A WojtalikShaun M Eack

Abstract

Individuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive enhancement therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample of outpatients with schizophrenia and alcohol and/or cannabis substance use problems participating in an 18-month randomized trial of CET (n = 10) or usual care (n = 4) completed posttreatment functional neuroimaging using an emotion regulation task. General linear models explored CET effects on brain activity in emotional neurocircuitry. Individuals treated with CET had significantly greater activation in broad regions of the prefrontal cortex, limbic, and striatal systems implicated in emotion regulation compared to usual care. Differential activation favoring CET in prefrontal regions and the insula mediated behavioral improvements in emotional processing. Our data lend preliminary support of CET effects on neuroplasticity in frontolimbic and striatal circuitries, which mediate emotion regulation in people with schizophrenia and comorbid substance misuse problems.

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Citations

Oct 8, 2016·The American Journal of Drug and Alcohol Abuse·Melanie E BennettLauren T Catalano
Dec 13, 2019·The Cochrane Database of Systematic Reviews·Glenn E HuntMichelle Cleary
Apr 6, 2018·Frontiers in Neuroscience·Arthur SaniotisAbdul-Rahman Sawalma

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Methods Mentioned

BETA
pharmacotherapies

Clinical Trials Mentioned

NCT01292577

Software Mentioned

AlphaSim
3dClustSim
SPM8
R
PSSCogReHab
Artifact Detection Tool
PickAtlas
Statistical Parametric Mapping Software

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