Cognitive-enhancing activities of the polyprenol preparation Ropren® in gonadectomized β-amyloid (25-35) rat model of Alzheimer's disease

Physiology & Behavior
Julia FedotovaLucian Hritcu

Abstract

The present preclinical study was designed to examine the effects of prolonged Ropren® administration (8.6 mg/kg, orally, once daily, 28 days) in a β-amyloid (25-35) rat model of Alzheimer's disease following gonadectomy. The experimental model was created by intracerebroventricular injection of β-amyloid (25-35) into gonadectomized (GDX) rats and GDX rats with testosterone propionate (TP, 0.5mg/kg, subcutaneous, once daily, 28 days) supplementation. Ropren® was administered to the GDX rats and GDX rats treated with TP. Memory performance was assessed using the passive avoidance and the Morris water maze tests and the spontaneous locomotor activity was assessed using the open field test. Treatment with Ropren® significantly improved and restored the cognitive ability of GDX rats with β-amyloid (25-35)-induced amnesia in the passive avoidance test and Morris water maze. Co-administration of Ropren® with TP exerted a markedly synergistic memory-enhancing effect in the GDX rats with β-amyloid (25-35)-induced amnesia on the same models of memory testing. Ropren® administered alone or together with TP significantly enhanced crossing, frequency of rearing and grooming of the GDX rats with β-amyloid (25-35)-induced amnesia in the open...Continue Reading

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Citations

Aug 18, 2017·Journal of Cellular and Molecular Medicine·Paula Alexandra PostuLucian Hritcu
Oct 17, 2017·Frontiers in Cellular Neuroscience·Elise C OhkiRichard C Chou
Oct 19, 2019·Current Drug Targets·Vivek Kumar Sharma, Thakur Gurjeet Singh
Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilona VanagaBaiba Jansone
Aug 12, 2020·Molecular and Cellular Biochemistry·Manman ChenLina Song

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