Cognitive flexibility but not cognitive coordination is affected in rats with toxic liver failure

Behavioural Brain Research
Malgorzata J WesierskaJan Albrecht

Abstract

Hepatic encephalopathy (HE), a consequence of liver damage, is associated with cognitive deficits. In this study, behavioral activity, non-associative learning, associative memory, cognitive coordination and flexibility were investigated in rats with subclinical HE evoked by thioacetamide treatment. Non-associative learning was studied in the open field (OF) set up in 12 HE and 8 saline-injected control rats (C). Memory was examined in spatial place avoidance tasks in 10 HE and 10 C rats. The Room+ Arena- task involved the selection of distal room stimuli from irrelevant arena stimuli (i.e. intramaze cues and/or self-motion information), which engages processes of cognitive coordination. Following the Room+ Arena- training, cognitive flexibility of rats was tested in the Arena+ place avoidance condition, which demands the previously ignored stimuli from arena. In the OF test HE and control rats behaved similar. They displayed high activity in the first block of each session and this pattern was stable. In both groups of rats darkness enhanced locomotor activity in comparison to light only in the first block. The HE and C rats avoided the to-be-avoided place in the Room+ Arena- task, whereas only HE rats were affected in the Are...Continue Reading

References

Oct 1, 1985·Experimental Neurology·F BengtssonE Rosengren
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·F BengtssonB Jeppsson
Nov 1, 1985·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·S P Tipper
Jul 30, 1969·Annals of the New York Academy of Sciences·V H Denenberg
Jun 13, 1970·British Medical Journal·R ZeegenA M Dawson
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·A CampbellJ E Fischer
Nov 22, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J BuresL Zinyuk
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A A FentonJ Bures
Sep 21, 2000·Behavioural Brain Research·M M van Gaalen, T Steckler
Oct 21, 2000·Journal of Neuroscience Methods·J M CimadevillaJ Bures
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A StuchlikJ Bures
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan Córdoba, Roy Lucke
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian WeinPeter Schauder
Jun 28, 2005·Schizophrenia Research·M VinkR S Kahn
Nov 5, 2005·Journal of Cognitive Neuroscience·Tobias Egner, Joy Hirsch
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrey V OlypherAndré A Fenton
Jun 1, 1995·Psychonomic Bulletin & Review·E Fox

❮ Previous
Next ❯

Citations

Aug 24, 2012·Canadian Journal of Physiology and Pharmacology·Dušan MladenovićOlivera Stanojlović
Apr 30, 2013·Archives of Biochemistry and Biophysics·Shuping WenNikolaj Klöcker
Mar 5, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M MéndezJ L Arias
Dec 6, 2008·Behavioural Brain Research·Marta MéndezJorge L Arias
Jun 3, 2008·Neurochemistry International·Mohammed Abul KashemIzuru Matsumoto
Dec 8, 2007·Behavioural Brain Research·Marta MéndezJorge L Arias
Sep 13, 2015·Molecular and Cellular Neurosciences·Annett SchroeterNikolaj Klöcker
Feb 22, 2008·Brain Research·Qing ZengJianren Mao
Jun 7, 2015·Physiology & Behavior·M Méndez-LópezJ L Arias
Dec 18, 2013·Physiological Research·A StuchlíkM Wesierska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.