Cognitive Frailty in Older People with Type 2 Diabetes Mellitus: the Central Role of Hypoglycaemia and the Need for Prevention

Current Diabetes Reports
A H Abdelhafiz, A J Sinclair

Abstract

To highlight the central role of hypoglycaemia in the causation of cognitive frailty and explore ways of recognition and prevention of hypoglycaemia. Cognitive frailty is an emerging new concept defined as the concomitant presence of physical frailty and cognitive impairment. In older people with diabetes, cognitive frailty is associated with an increased risk of mortality greater than from either physical frailty or cognitive impairment alone. Hypoglycaemia is directly associated with increased risk of cognitive impairment and physical frailty which are the two components of cognitive frailty. The incidence of hypoglycaemia in older people with diabetes is rising and hypoglycaemia-related hospitalisation has overtaken that of hyperglycaemia. Recognition of hypoglycaemic episodes in old age remains challenging which leads to misdiagnoses and under-reporting. Therefore, hypoglycaemia prevention strategies are needed. Research is still required to investigate whether prevention of hypoglycaemia would lead to a reduction in the incidence of cognitive frailty.

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Dec 16, 2004·Diabetologia·S MaggiUNKNOWN ILSA Group
Jul 19, 2005·Neurobiology of Aging·Francesco PanzaVincenzo Solfrizzi
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Mar 17, 2007·Diabetes Care·Seok Won ParkUNKNOWN Health, Aging, and Body Composition Study
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Rachel A WhitmerJoseph V Selby
May 14, 2009·American Journal of Physiology. Endocrinology and Metabolism·Adam J BreeSimon J Fisher
Aug 18, 2009·Journal of the American Geriatrics Society·Tara L GruenewaldCatherine A Sarkisian
Oct 14, 2009·Archives of Neurology·Laura E Middleton, Kristine Yaffe
Nov 28, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruth E HubbardKenneth Rockwood
Dec 25, 2009·Diabetes Care·Thomas DuningBjörn Ellger
Apr 28, 2010·Journal of Alzheimer's Disease : JAD·Vincenza FrisardiFrancesco Panza
Sep 21, 2010·Ageing Research Reviews·N M de VriesM W G Nijhuis-van der Sanden
Mar 2, 2011·Archives of Internal Medicine·Medha N MunshiKatie Weinger
Apr 15, 2011·Neurology·J LiUNKNOWN Chongqing Ageing Study Group
Jun 16, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·R GadsbyA Sinclair
Oct 26, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·P P AungUNKNOWN Edinburgh Type 2 Diabetes Study Investigators
Nov 22, 2011·Journal of Nutrition in Gerontology and Geriatrics·Roschelle A Heuberger
Jan 4, 2012·Diabetes & Metabolism·Alan J SinclairUNKNOWN European Diabetes Working Party for Older People
Jan 12, 2012·Geriatrics & Gerontology International·Tanneguy PialouxBruno Lesourd
Mar 21, 2012·Journal of the American Geriatrics Society·Carolyn T ThorpeMaureen A Smith
Sep 26, 2012·Journal of Internal Medicine·C-H Lin, W H-H Sheu
Jun 12, 2013·JAMA Internal Medicine·Kristine YaffeUNKNOWN Health ABC Study
Jul 9, 2013·Ageing Research Reviews·Deirdre A RobertsonRose Anne Kenny
Oct 10, 2013·Diabetes Care·Insa FeinkohlUNKNOWN Edinburgh Type 2 Diabetes Study (ET2DS) Investigators
Oct 25, 2013·The Journal of Nutrition, Health & Aging·E KelaiditiUNKNOWN IANA/IAGG
Mar 14, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Angela PassaroGiovanni Zuliani
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Evelyn WongAnna Peeters
Apr 8, 2014·Diabetes & Metabolism·L BordierB Bauduceau
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Rita Rastogi KalyaniLuigi Ferrucci
Dec 3, 2014·Journal of the American Medical Directors Association·John E MorleyAlan J Sinclair
Jan 13, 2015·JAMA Internal Medicine·Kasia J LipskaMichael A Steinman
Feb 11, 2015·Acta Diabetologica·Antonio NicolucciRenato Lauro

❮ Previous
Next ❯

Citations

Feb 17, 2019·Current Diabetes Reports·Kristin K ClemensJinnie J Rhee
Jan 11, 2021·Endocrinología, Diabetes Y Nutrición·Rebeca Reyes-GarcíaUNKNOWN Grupo de Trabajo de Diabetes Mellitus de la Sociedad Española de Endocrinología y Nutrición (SEEN)
Jan 27, 2020·Mechanisms of Ageing and Development·Catia ScassellatiCristina Geroldi
Sep 10, 2020·Journal of Diabetes and Its Complications·Serena LowSu Chi Lim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Cardiovascular Nursing
Lola A Coke, Cheryl R Dennison Himmelfarb
International Journal of Clinical Practice
A H AbdelhafizA J Sinclair
British Journal of Hospital Medicine
Sindu MohanJacob F de Wolff
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Thushan S Hettige, Mark E Cooper
© 2022 Meta ULC. All rights reserved