Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls

Journal of Psychopharmacology
C T J LamersJohannes G Ramaekers

Abstract

Repeated ecstasy (MDMA) use is reported to impair cognition and cause increased feelings of depression and anxiety. Yet, many relevant studies have failed to control for use of drugs other than MDMA, especially marijuana (THC). To address these confounding effects we compared behavioural performance of 11 MDMA/THC users, 15 THC users and 15 non-drug users matched for age and intellect. We tested the hypothesis that reported feelings of depression and anxiety and cognitive impairment (memory, executive function and decision making) are more severe in MDMA/THC users than in THC users. MDMA/THC users reported more intense feelings of depression and anxiety than THC users and non-drug users. Memory function was impaired in both groups of drug users. MDMA/THC users showed slower psychomotor speed and less mental flexibility than non-drug users. THC users exhibited less mental flexibility and performed worse on the decision making task compared to non-drug users but these functions were similar to those in MDMA/THC users. It was concluded that MDMA use is associated with increased feelings of depression and anxiety compared to THC users and non-drug users. THC users were impaired in some cognitive abilities to the same degree as MDMA...Continue Reading

References

Jan 1, 1992·Journal of Substance Abuse Treatment·A T McLellanM Argeriou
Mar 1, 1991·Psychological Bulletin·C M MacLeod
Sep 1, 1968·The American Journal of Psychiatry·W H McGlothlin, L J West
Apr 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·U D McCannG A Ricaurte
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Aug 13, 1998·Pharmacology, Biochemistry, and Behavior·R V FantW B Pickworth
Aug 27, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M J Morgan
Oct 27, 1998·Drug and Alcohol Dependence·F SchifanoR Bricolo
Dec 8, 1998·Lancet·W Hall, N Solowij
Dec 17, 1998·Neurology·K I BollaG A Ricaurte
Feb 13, 1999·International Clinical Psychopharmacology·G GerraR Delsignore
Jan 6, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D M SempleE C Johnstone
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Meneses
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·C S CarterJ D Cohen
Feb 23, 2000·Neuroreport·A GammaF X Vollenweider
May 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·E Gouzoulis-MayfrankH Sass
Jul 26, 2000·Neurology·S J KishK S Kalasinsky
Feb 24, 2001·Psychopharmacology·R J VerkesA F Cohen
Mar 29, 2001·Psychopharmacology·R J CroftJ G Gruzelier
Nov 15, 2001·Current Psychiatry Reports·H G PopeD Yurgelun-Todd
Nov 17, 2001·Psychiatry Research·L A TownsendR M Norman
Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Liesbeth RenemanJan Booij
Mar 7, 2002·JAMA : the Journal of the American Medical Association·Nadia SolowijUNKNOWN Marijuana Treatment Project Research Group
Apr 10, 2002·Acta Neurologica Scandinavica·M T RattiD Soragna

❮ Previous
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Citations

Jan 22, 2010·Psychopharmacology·Lynn HuesteggeRalph Radach
Feb 17, 2010·Neuropsychology Review·Claire E NulsenGeoffrey R Hammond
Mar 24, 2012·Journal of Clinical and Experimental Neuropsychology·Merel F H Griffith-LenderingHanna Swaab
Oct 22, 2013·Psychopharmacology·Simon N YoungChawki Benkelfat
Apr 27, 2010·Journal of Mathematical Psychology·Daniel J FridbergJulie C Stout
Apr 4, 2008·Drug and Alcohol Dependence·Karen L HansonKristin Sullwold
Mar 12, 2016·Psychological Medicine·C A RobertsC Montgomery
Nov 11, 2008·Annals of the New York Academy of Sciences·Saturnino SpigaMarco Diana
Dec 25, 2010·Addiction·John E FiskFlorentia Hadjiefthyvoulou
Apr 13, 2010·Accident; Analysis and Prevention·Elizabeth DastrupMatthew Rizzo
Jul 16, 2011·Pharmacology, Biochemistry, and Behavior·Wael M Y MohamedByron C Jones
Jul 23, 2015·Drug and Alcohol Dependence·Raul GonzalezKathleen R Diviak
Apr 21, 2016·Neuroscience and Biobehavioral Reviews·Liana Fattore, Marco Diana
Mar 5, 2011·Neurobiology of Learning and Memory·C KayM Hunt
Nov 20, 2016·The European Journal of Neuroscience·Felix BetzlerNina Romanczuk-Seiferth
Jan 19, 2010·Journal of Psychopharmacology·Ana B FagundoRafael de la Torre
Jun 20, 2008·Journal of Psychopharmacology·L HuesteggeH J Kunert
Jan 23, 2008·Journal of Psychopharmacology·S de Sola LlopisR de la Torre
Jul 19, 2008·Journal of Psychopharmacology·K SoarJ Turner
Apr 28, 2018·International Journal of Environmental Research and Public Health·Zoran ZubakHaris Pojskic
Jan 12, 2019·The European Journal of Neuroscience·Leonard ViohlFelix Betzler
Jul 11, 2007·Human Psychopharmacology·Keith R Laws, Joy Kokkalis
Sep 27, 2007·Human Psychopharmacology·Konstantine K ZakzanisDiana Jovanovski
Mar 31, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johannes G RamaekersManfred R Moeller
Feb 2, 2021·Psychological Reports·Robert I BlockNick F Ramsey

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