Cognitive function and the costs of Alzheimer disease. An exploratory study

Archives of Neurology
R L ErnstJ A Yesavage

Abstract

To estimate the dollar savings in costs attainable from drug or other treatments for Alzheimer disease (AD) that stabilize or reverse patients' cognitive decline. Medical and other disease-related utilization data were collected from the caregivers of 64 patients diagnosed as having probable AD. The quantities of utilization were priced at national levels to generate measures of illness costs. Costs per patient were then estimated as regression functions of scores on the Mini-Mental State Examination (MMSE), which was used as an index of patient cognitive function. Potential savings in illness costs were estimated by comparing predicted costs at various baseline and intervention-level values of the patient's MMSE score. The potential savings in illness costs attainable from treatment are small for mildly and very severely demented patients with AD. However, for moderately to severely demented home-dwelling patients having, say, an MMSE score of 7 at baseline, prevention of a 2-point decline in the score would save about $3700 annually, and a 2-point increase in an MMSE score rather than a 2-point decline would save about $7100. Large savings in the costs of caring for moderately to severely demented home-dwelling patients with ...Continue Reading

Citations

Dec 24, 2002·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Edith G WalshLisa F Berkmann
Jul 21, 2006·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Perla WernerAmos Korczyn
Nov 30, 2007·Clinical Interventions in Aging·Carolyn W Zhu, Mary Sano
Jul 15, 2009·The Gerontologist·Richard H FortinskyAlison Kleppinger
Sep 18, 2001·Journal of the American Geriatrics Society·K Brummel-Smith
Aug 30, 2005·Issues in Mental Health Nursing·Catherine S Cole, Kathy C Richards
Dec 18, 2015·Neuropsychological Rehabilitation·Amanda L GoodingMonica Rivera Mindt
Dec 29, 2000·Journal of the American Geriatrics Society·P J NeumannE M Gutterman
Nov 28, 2007·Annual Review of Pathology·Daniel M SkovronskyJohn Q Trojanowski
Jun 3, 2004·Neurobiology of Aging·Edward ZamriniMartin Tolar
Sep 3, 2004·Journal of the American Geriatrics Society·Joshua ChodoshDavid B Reuben
Apr 1, 2006·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·J Wesson AshfordHerman Buschke
May 13, 2011·American Journal of Alzheimer's Disease and Other Dementias·Josephine Mauskopf, Lisa Mucha
Apr 13, 2012·American Journal of Alzheimer's Disease and Other Dementias·Judith BentkoverVincent Mor
Dec 20, 2002·Journal of Geriatric Psychiatry and Neurology·Ruth O'HaraJared R Tinklenberg
Sep 12, 2003·Journal of Geriatric Psychiatry and Neurology·Anne-Sophie RigaudFrançoise Forette
Jul 27, 2000·Journal of Geriatric Psychiatry and Neurology·R CamicioliP Butterfield
Aug 14, 1999·Journal of Geriatric Psychiatry and Neurology·M Trabucchi
Sep 11, 1998·International Journal of Geriatric Psychiatry·M KnappR Wigglesworth
May 25, 2002·Journal of the American Geriatrics Society·Gary W SmallGeorge Papadopoulos
Jan 6, 2000·PharmacoEconomics·L JönssonB Winblad
Apr 21, 2009·Journal of Empirical Research on Human Research Ethics : JERHRE·Aimee-Marie DorstenHoward Wactlar
Aug 9, 2002·Headache·John Edmeads, Joan A Mackell
Jul 16, 2005·International Journal of Geriatric Psychiatry·M ZencirT Sahiner
May 6, 2006·International Journal of Geriatric Psychiatry·Linus JönssonAnders Wimo
Oct 18, 2018·Nutritional Neuroscience·Krista ChristensenJulie A Mares
Jan 15, 2009·Annals of Nuclear Medicine·Nobuyoshi FukumitsuKiichi Ishiwata
Apr 20, 2005·PharmacoEconomics·Daniel L Murman, Christopher C Colenda
Jul 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·J WolstenholmeT Hope
Feb 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Shane Kavanagh, Martin Knapp
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S Kavanagh, M Knapp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.