Cognitive function does not worsen during long-term low-dose peginterferon therapy in patients with chronic hepatitis C.

The American Journal of Gastroenterology
Robert J FontanaHALT-C Trial Group

Abstract

Neuropsychiatric toxicity is a common dose-limiting side effect of interferon therapy. The primary aim of this study was to determine whether patients receiving long-term low-dose peginterferon therapy had a higher incidence of cognitive side effects compared with untreated patients enrolled in the Hepatitis C Antiviral Long-Term treatment against Cirrhosis (HALT-C) Trial. A total of 129 patients with chronic hepatitis C and advanced fibrosis completed a battery of 10 neuropsychological tests and the Beck Depression Inventory at pretreatment baseline and at months 12, 24, 36, and 48 while receiving long-term peginterferonalpha2a (90 microg/week) or no therapy during the randomized phase of the HALT-C Trial. Cognitive impairment was defined as a global deficit score (GDS) > or = 1.0. The mean age was 51.2 years, 67% were male, and 42% had cirrhosis. After accounting for baseline GDS scores, the mean GDS scores did not significantly change over time (P=0.46) nor with treatment group (P=0.49). Cognitive function was also not influenced by medication adherence in the 66 patients receiving maintenance peginterferon (P=0.14) after controlling for baseline GDS scores and time. Beck Depression scores did not significantly increase over...Continue Reading

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Citations

May 23, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S Bajaj, Daniel M Forton
Aug 14, 2019·Journal of Clinical and Experimental Neuropsychology·Zahra AmirsardariNima Rezaei
Dec 12, 2017·Biomedical Research·Hiroto Tanaka, Hideyuki Sasaki

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