Cognitive function in patients on androgen suppression: A prospective, multicentric study.

Actas urologicas españolas
Juan MoroteGrupo de investigación ANAMEM

Abstract

To assess the effect of androgen deprivation therapy (ADT) on cognitive performance (CP) in patients with prostate cancer (PCa) after 6 months of treatment with luteinizing hormone-releasing hormone (LHRH) analogues. Prospective, observational, multicentre, open-label study of patients diagnosed with nonmetastatic or asymptomatic metastatic PCa scheduled to receive LHRH analogues for≥6 months. We assessed four CP domains at baseline and after 6 months of ADT: 1) Working memory: Wechsler Adult Intelligence Scale III (WAIS III) Digit Span Subtest (WAIS III-Digit); 2) Visual memory: ad hoc visual memory test; 3) Visuospatial ability: Judgement of Line Orientation (JLO) and Mental Rotation of Three-Dimensional Objects (3D-Rotation); and 4) Nonverbal analytical reasoning: WAIS III Matrix Reasoning Test (WAIS III-MRT). Changes outside the baseline 95% confidence intervals were considered significant. A total of 308 patients completed the study. Of these, 245 (79.6%) experienced no statistically significant changes on any test and 63 patients (20.4%) experienced significant changes in ≥1 test. Of these, most presented a change in only one test, distributed evenly between improvements (58 patients; 18.8%) and worsening (56 patients; 18...Continue Reading

Citations

Feb 27, 2019·Current Osteoporosis Reports·Robert J PignoloAbhishek Chandra
Jun 21, 2018·Frontiers in Endocrinology·Daniel J TobianskyKiran K Soma
Jun 11, 2021·Sexual Medicine Reviews·Martin M Muermann, Richard J Wassersug
Jun 16, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Cornelie D AndelaA Edo Meinders

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