Cognitive function in unipolar major depression: a comparison of currently depressed, previously depressed, and never depressed individuals

Journal of Clinical and Experimental Neuropsychology
Marianne HalvorsenKnut Waterloo

Abstract

There is a lack of consensus upon a conclusive cognitive profile characterizing unipolar major depression. Currently depressed (n = 37), recovered previously depressed (n = 81), and never depressed controls (n = 50) underwent assessment of executive functions, working memory, attention, and psychomotor speed. Currently depressed yielded significantly lower test scores than previously and never depressed subjects on a measure of working memory. Both currently depressed and previously depressed scored significantly lower than never depressed subjects on measures of processing speed. Recurrent depressed performed similarly to subjects with a single depressive episode. These findings indicate a mild and limited cognitive impairment during the course of a mild to moderate major depressive disorder among relatively young adults. Impaired processing speed should be considered in further studies as a potential irreversible marker for recurrent depression.

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Citations

Feb 22, 2014·European Archives of Psychiatry and Clinical Neuroscience·Heidelore BackesAxel Krug
Apr 20, 2016·Human Brain Mapping·Timm B PoepplSimon B Eickhoff
Jun 3, 2016·Journal of Affective Disorders·Christine Mohn, Bjørn Rishovd Rund
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Nov 6, 2020·The Clinical Neuropsychologist·Allyson G HarrisonIrene T Armstrong

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