Cognitive Function Is Impaired in Patients with Recently Diagnosed Type 2 Diabetes, but Not Type 1 Diabetes

Journal of Diabetes Research
Theresa van GemertGDS Group

Abstract

To test whether cognitive function is impaired in early states of diabetes and to identify possible risk factors for cognitive impairment. A cross-sectional analysis within the German Diabetes Study included patients with type 1 or type 2 diabetes within the first year after diagnosis or five years after study inclusion and metabolically healthy individuals. Participants underwent comprehensive metabolic phenotyping and testing of different domains of cognitive function. Linear regression models were used to compare cognition test outcomes and to test associations between cognitive function and possible influencing factors within the groups. In participants with recently diagnosed diabetes, verbal memory was poorer in patients with type 2 diabetes (P = 0.029), but not in type 1 diabetes (P = 0.156), when compared to healthy individuals. Five years after diagnosis, type 2 diabetes patients also showed lower verbal memory than those with type 1 diabetes (P = 0.012). In addition to crystallized intelligence, a higher body mass index among individuals with recently diagnosed type 2 diabetes and male sex among individuals with recently diagnosed type 1 diabetes were associated with impaired verbal memory (all P < 0.05). Verbal memor...Continue Reading

References

Mar 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·R N Bale
Dec 1, 1984·The American Journal of Medicine·L C PerlmuterD M Nathan
Oct 12, 2000·Diabetes/metabolism Research and Reviews·C M Ryan, M Geckle
Oct 21, 2000·Progress in Neurobiology·L M Garcia-SeguraL L DonCarlos
Oct 1, 1955·Journal of Consulting Psychology·R M REITAN
Dec 1, 2007·Epidemiology·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Apr 4, 2008·Journal of the American Geriatrics Society·Olivia I OkerekeFrancine Grodstein
Aug 30, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Magdy SelimVera Novak
Oct 14, 2008·Biochimica Et Biophysica Acta·Esther van den BergGeert Jan Biessels
Apr 16, 2009·Diabetes Care·Carla RuisGuy E H M Rutten
Aug 28, 2010·Diabetes·Jie DingUNKNOWN Edinburgh Type 2 Diabetes Study Investigators
Feb 5, 2011·Diabetes/metabolism Research and Reviews·Yael D ReijmerUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Jun 12, 2012·Lancet·Rory J McCrimmonBrian M Frier
Jan 1, 2013·Diabetes Care·Peggy J J SpauwenMartin P J van Boxtel
Dec 2, 2014·Annals of Internal Medicine·Andreea M RawlingsElizabeth Selvin
Nov 12, 2015·Comprehensive Psychiatry·Bao Hua ZhangXu Feng Huang
Apr 8, 2016·Cardiovascular Diabetology·Julia SzendroediUNKNOWN GDS Group
Sep 24, 2016·World Journal of Diabetes·Elham SaediMohammad Ali Arami
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Jul 28, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bradley J BaranowskiRebecca E K MacPherson
Feb 15, 2019·Frontiers in Endocrinology·Anup BhusalKyoungho Suk
Nov 6, 2020·Current Neurology and Neuroscience Reports·Zoe ArvanitakisDavid A Bennett
Jan 21, 2021·International Journal of Molecular Sciences·So Yeong Cheon, Juhyun Song
Apr 28, 2021·Diabetes Care·Allison L B ShapiroUNKNOWN SEARCH for Diabetes in Youth Study Group
Jun 27, 2021·Nature Reviews. Endocrinology·Srikanth BellaryClifford J Bailey

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01055093

Software Mentioned

SAS

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.