Abstract
Despite the increasing use of lamotrigine (LTG) in bipolar disorder, little is known about its impact on cognition in bipolar patients. Therefore, we have evaluated 33 bipolar I and II patients on cognitive measures (verbal memory, attention, executive functions) while receiving either LTG (n = 15) or another anticonvulsant (carbamazepine or valproate; n = 18). Patients receiving LTG were generally diagnosed as having bipolar II disorder, had experienced more depressive episodes but a lesser number of hospitalizations, and had better performance than the patients receiving carbamazepine or valproate on the verbal fluency task. A moderate effect size also suggests that both groups may differ on the immediate verbal memory test (California Verbal Learning Test). These preliminary results suggest a safer neurocognitive profile of LTG on bipolar patients, as compared with other anticonvulsants.
References
Mar 1, 1990·Epilepsy Research·R GallassiA Baruzzi
Jan 1, 1984·Epilepsia·M R Trimble, P J Thompson
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·R P WiardB R Cooper
Jan 1, 1993·Epilepsia·M J HamiltonA W Peck
Jan 22, 1998·Archives of General Psychiatry·W G van GorpW Dixon
Aug 13, 1998·Seizure : the Journal of the British Epilepsy Association·P Crawford
Feb 5, 1999·Neurology·R MartinE Faught
Mar 20, 1999·The Journal of Clinical Psychiatry·J R CalabreseG D Rudd
Jan 25, 2000·The British Journal of Psychiatry : the Journal of Mental Science·I N FerrierJ Scott
May 23, 2001·Psychiatry Research·J K ZubietaB J Giordani
Mar 7, 2002·Epilepsia·A P AldenkampJ de Vocht
Feb 7, 2003·Neuropsychobiology·A Martinez-AranM Salamero
Mar 18, 2003·Journal of Clinical Psychopharmacology·Carrie L Ernst, Joseph F Goldberg
Jun 26, 2003·Epilepsia·Albert P AldenkampRianne Reijs
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Joseph R CalabreseMelvin D Shelton
Feb 3, 2004·The American Journal of Psychiatry·Anabel Martínez-AránManel Salamero
May 1, 2004·Bipolar Disorders·A Martínez-AránM Salamero
Sep 14, 2004·CNS Spectrums·Claudia F BaldassanoJohn P O'Reardon
Sep 16, 2004·The Annals of Pharmacotherapy·Oriano MecarelliNeri Accornero
Oct 13, 2004·Biological Psychiatry·Lori L AltshulerJim Mintz
Oct 27, 2004·Psychological Medicine·T DixonP K McGuire
Nov 24, 2004·The Journal of Clinical Psychiatry·Arifulla KhanBryan E Adams
Jun 30, 2005·Neurology·K J MeadorR P Kustra
Citations
Oct 19, 2006·Biological Psychiatry·Luke ClarkBarbara J Sahakian
Jul 31, 2012·Journal of Affective Disorders·I GrandeUNKNOWN SIN-DEPRES Group
Nov 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Sherwood BrownI Julian Osuji
Feb 26, 2010·Applied Neuropsychology·Grant L IversonAllan H Young
Jun 6, 2009·Harvard Review of Psychiatry·Boaz Levy, Roger D Weiss
Nov 21, 2007·CNS Drugs·Katherine E BurdickAnil K Malhotra
Sep 18, 2009·Psychiatry Research·Eva María Sánchez-MorlaJosé Luis Santos Gómez
Oct 11, 2012·Case Reports in Medicine·Katsumasa MuneokaShou Kimura
Jun 12, 2012·Depression Research and Treatment·R Lopes, L Fernandes
Oct 20, 2009·European Journal of Pharmacology·Vicent Balanzá-MartínezRafael Tabarés-Seisdedos
Nov 11, 2014·American Journal of Therapeutics·Marsal SanchesJair C Soares
Nov 16, 2007·Journal of Geriatric Psychiatry and Neurology·John O Brooks, Jennifer C Hoblyn
Dec 1, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Frédéric CoppolaEmilie Olié
Feb 22, 2013·Journal of Clinical Pharmacology·Felix M SegmillerAlexander Brunnauer
Nov 13, 2009·Acta Psychiatrica Scandinavica·Eduard Vieta
Apr 21, 2010·Bipolar Disorders·Mani N PavuluriJohn A Sweeney
Jun 23, 2009·Bipolar Disorders·Joseph F Goldberg, K N Roy Chengappa
Jun 19, 2015·Current Psychiatry Reports·Andrea MurruEduard Vieta
Sep 18, 2010·Acta Psychiatrica Scandinavica·B ArtsJ van Os
Dec 7, 2019·CNS Drugs·Ni XuKate E A Saunders
Sep 30, 2017·The Journal of Nervous and Mental Disease·Gabriele CiprianiMario Di Fiorino
Nov 12, 2015·Frontiers in Pharmacology·Kedar S PrabhavalkarLokesh K Bhatt
Aug 14, 2012·Acta Psychiatrica Scandinavica·V V DiasE Vieta
Mar 19, 2021·Revista colombiana de psiquiatría·Stephen Baena-OquendoCarlos López-Jaramillo
May 27, 2021·The International Journal of Neuropsychopharmacology·Alexander BrunnauerGerd Laux