Cognitive functioning in bipolar patients receiving lamotrigine: preliminary results

Journal of Clinical Psychopharmacology
Claire DabanEduard Vieta

Abstract

Despite the increasing use of lamotrigine (LTG) in bipolar disorder, little is known about its impact on cognition in bipolar patients. Therefore, we have evaluated 33 bipolar I and II patients on cognitive measures (verbal memory, attention, executive functions) while receiving either LTG (n = 15) or another anticonvulsant (carbamazepine or valproate; n = 18). Patients receiving LTG were generally diagnosed as having bipolar II disorder, had experienced more depressive episodes but a lesser number of hospitalizations, and had better performance than the patients receiving carbamazepine or valproate on the verbal fluency task. A moderate effect size also suggests that both groups may differ on the immediate verbal memory test (California Verbal Learning Test). These preliminary results suggest a safer neurocognitive profile of LTG on bipolar patients, as compared with other anticonvulsants.

References

Mar 1, 1990·Epilepsy Research·R GallassiA Baruzzi
Jan 1, 1984·Epilepsia·M R Trimble, P J Thompson
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·R P WiardB R Cooper
Aug 13, 1998·Seizure : the Journal of the British Epilepsy Association·P Crawford
Jan 25, 2000·The British Journal of Psychiatry : the Journal of Mental Science·I N FerrierJ Scott
May 23, 2001·Psychiatry Research·J K ZubietaB J Giordani
Feb 7, 2003·Neuropsychobiology·A Martinez-AranM Salamero
Mar 18, 2003·Journal of Clinical Psychopharmacology·Carrie L Ernst, Joseph F Goldberg
Jun 26, 2003·Epilepsia·Albert P AldenkampRianne Reijs
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Joseph R CalabreseMelvin D Shelton
Feb 3, 2004·The American Journal of Psychiatry·Anabel Martínez-AránManel Salamero
Sep 14, 2004·CNS Spectrums·Claudia F BaldassanoJohn P O'Reardon
Oct 27, 2004·Psychological Medicine·T DixonP K McGuire
Nov 24, 2004·The Journal of Clinical Psychiatry·Arifulla KhanBryan E Adams

❮ Previous
Next ❯

Citations

Jul 31, 2012·Journal of Affective Disorders·I GrandeUNKNOWN SIN-DEPRES Group
Nov 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Sherwood BrownI Julian Osuji
Feb 26, 2010·Applied Neuropsychology·Grant L IversonAllan H Young
Nov 21, 2007·CNS Drugs·Katherine E BurdickAnil K Malhotra
Sep 18, 2009·Psychiatry Research·Eva María Sánchez-MorlaJosé Luis Santos Gómez
Jun 12, 2012·Depression Research and Treatment·R Lopes, L Fernandes
Oct 20, 2009·European Journal of Pharmacology·Vicent Balanzá-MartínezRafael Tabarés-Seisdedos
Nov 11, 2014·American Journal of Therapeutics·Marsal SanchesJair C Soares
Nov 16, 2007·Journal of Geriatric Psychiatry and Neurology·John O Brooks, Jennifer C Hoblyn
Dec 1, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Frédéric CoppolaEmilie Olié
Feb 22, 2013·Journal of Clinical Pharmacology·Felix M SegmillerAlexander Brunnauer
Nov 13, 2009·Acta Psychiatrica Scandinavica·Eduard Vieta
Apr 21, 2010·Bipolar Disorders·Mani N PavuluriJohn A Sweeney
Jun 23, 2009·Bipolar Disorders·Joseph F Goldberg, K N Roy Chengappa
Jun 19, 2015·Current Psychiatry Reports·Andrea MurruEduard Vieta
Sep 18, 2010·Acta Psychiatrica Scandinavica·B ArtsJ van Os
Sep 30, 2017·The Journal of Nervous and Mental Disease·Gabriele CiprianiMario Di Fiorino
Nov 12, 2015·Frontiers in Pharmacology·Kedar S PrabhavalkarLokesh K Bhatt
Mar 19, 2021·Revista colombiana de psiquiatría·Stephen Baena-OquendoCarlos López-Jaramillo
May 27, 2021·The International Journal of Neuropsychopharmacology·Alexander BrunnauerGerd Laux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.