Nov 8, 2018

Cognitive functions and jugular venous reflux in severe mitral regurgitation

BioRxiv : the Preprint Server for Biology
Shih-Hsien SungChih-Ping Chung


Cardiac diseases with elevated central venous pressure have higher frequency of jugular venous reflux (JVR), which is associated with decreased cerebral blood flow and white matter hyperintensities. Whether patients with severe mitral-regurgitation (SMR) have poorer cognitive functions and whether JVR is involved were determined. Patients with SMR and age/sex-matched controls were prospectively recruited. Neuropsychological tests such as global cognitive (Mini-Mental State Examination, MMSE), verbal memory, executive, and visuospatial domains were performed. Cardiac parameters by cardiac catheterisation and echocardiography, and the frequency of JVR by colour-coded duplex ultrasonography were obtained. Forty patients with SMR and 40 controls (71.1±12.2, 38–89 years; 75% men) were included. Compared with the controls, patients with SMR had lower scores in all neuropsychological tests but only MMSE and visuospatial test scores were statistically significant after adjusting for age, sex, and educational level. We further adjusted for cardiovascular risk factors; the significance remained in the visuospatial test but diminished in MMSE. Multivariate linear regression analyses adjusted for age, sex, and educational level showed that...Continue Reading

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Mentioned in this Paper

Mini-mental State Examination
Cerebral Blood Flow Imaging
Venous Blood Pressure
MSLN protein, human
Cardiac Catheterization Procedures
Blood Flow
Mitral Valve Insufficiency
Cardiac Catheterization Central Venous Pressure in Centimeters of H20
White Matter Hyperintensities

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