Cognitive functions of cortical ACh: lessons from studies on trans-synaptic modulation of activated efflux

Trends in Neurosciences
M Sarter, J P Bruno

Abstract

Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortical ACh. Bilateral modulation of basal forebrain GABAergic transmission by benzodiazepine-receptor agonists and inverse agonists decreases and increases, respectively, activated cortical ACh efflux. The determination of behavioral functions which are mediated via activated cortical ACh efflux, and therefore subject to the effects of basal forebrain GABA-cholinergic manipulations, should promote analyses of the functions of cortical ACh. Trans-synaptic approaches to enhance activated cortical ACh efflux offer some potential for the treatment of cognitive dysfunctions associated with impaired cortical cholinergic transmission.

References

Sep 1, 1992·British Journal of Pharmacology·J A MillerJ M Kane
Dec 1, 1992·Synapse·J Day, H C Fibiger
Jan 1, 1991·Progress in Neurobiology·N J Woolf
Jan 1, 1988·Trends in Neurosciences·M SarterD N Stephens
Jan 1, 1984·Psychopharmacology·L H JensenR Schmiechen
Mar 15, 1984·Biochemical Pharmacology·C BraestrupL H Jensen
Jan 1, 1993·Psychopharmacology·H S Koelega

❮ Previous
Next ❯

Citations

Nov 1, 1995·Brain Research. Brain Research Reviews·A Blokland
Mar 1, 1995·Behavioural Brain Research·T Steckler, A Sahgal
May 5, 2001·Brain Research. Brain Research Reviews·M SarterJ P Bruno
Feb 1, 1997·Brain Research. Brain Research Reviews·M Sarter, J P Bruno
Mar 1, 1997·Behavioural Brain Research·B Givens, M Sarter
Aug 29, 1998·Behavioural Brain Research·G G BerntsonJ T Cacioppo
May 23, 2001·Journal of Pain and Symptom Management·N E SlatkinT M Bolton
Sep 7, 2000·Neurotoxicology and Teratology·P J BushnellD M Warburton
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin SarterVinay Parikh
Jul 9, 2002·The European Journal of Neuroscience·Martin Sarter, John P Bruno
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·M I Miranda, F Bermúdez-Rattoni
Jan 31, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jason L CaseLisa A VanWormer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.