Cognitive Impairment and Mortality in a Population-Based Parkinson's Disease Cohort

Journal of Parkinson's Disease
Adrienne M KeenerBeate Ritz

Abstract

Parkinson's disease (PD) is a heterogeneous disorder with variability in phenotype and progression. We describe characteristics of PD patients in the largest population-based cohort followed for progression to date, and evaluate clinical risk factors for cognitive impairment and mortality. We collected longitudinal data using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Exam (MMSE), and Geriatric Depression Scale (GDS) in 242 new-onset PD patients followed for progression. We compared those who developed cognitive impairment (MMSE≤24) with those who did not, using t-tests, chi-square tests, and Cox proportional hazards regression. Mortality risk factors were assessed in all 360 patients enrolled at baseline. Thirty-four patients developed cognitive impairment during follow-up. Baseline characteristics predictive of faster time to cognitive impairment were older age at diagnosis, fewer years of education, and longer average sleep duration reported. The 197 patients who died were older at diagnosis, reported longer average sleep duration, had lower baseline MMSE scores, higher UPDRS-III scores, and a higher proportion were of the postural instability gait difficulty (PIGD) subtype. Patients with the tre...Continue Reading

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Citations

Aug 18, 2020·Neuropsychiatric Disease and Treatment·Hongmei LiuYiru Fang
Dec 7, 2020·Journal of Movement Disorders·Peter Cornelis PoortvlietGeorge D Mellick
Mar 16, 2021·Journal of Parkinson's Disease·Julie M ChandlerNick Patel

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