Cognitive impairment and neurogenotoxic effects in rats exposed to low-intensity microwave radiation

International Journal of Toxicology
Pravin Suryakantrao DeshmukhPramod Kumari Mediratta

Abstract

The health hazard of microwave radiation (MWR) has become a recent subject of interest as a result of the enormous increase in mobile phone usage. The present study aimed to investigate the effects of chronic low-intensity microwave exposure on cognitive function, heat shock protein 70 (HSP70), and DNA damage in rat brain. Experiments were performed on male Fischer rats exposed to MWR for 180 days at 3 different frequencies, namely, 900, 1800 MHz, and 2450 MHz. Animals were divided into 4 groups: group I: sham exposed; group II: exposed to MWR at 900 MHz, specific absorption rate (SAR) 5.953 × 10(-4) W/kg; group III: exposed to 1800 MHz, SAR 5.835 × 10(-4) W/kg; and group IV: exposed to 2450 MHz, SAR 6.672 × 10(-4) W/kg. All the rats were tested for cognitive function at the end of the exposure period and were subsequently sacrificed to collect brain. Level of HSP70 was estimated by enzyme-linked immunotarget assay and DNA damage was assessed using alkaline comet assay in all the groups. The results showed declined cognitive function, elevated HSP70 level, and DNA damage in the brain of microwave-exposed animals. The results indicated that, chronic low-intensity microwave exposure in the frequency range of 900 to 2450 MHz may c...Continue Reading

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Citations

Jan 10, 2017·International Journal of Radiation Biology·Elena G NovoselovaEugeny E Fesenko
Dec 8, 2017·Frontiers in Public Health·Lena K HedendahlLennart Hardell
Jan 24, 2019·Electromagnetic Biology and Medicine·Mehmet Esref AlkisMehmet Zulkuf Akdag
Feb 6, 2019·Environmental Science and Pollution Research International·Ranjeet KumarBasuDev Banerjee
Jan 26, 2018·International Journal of Radiation Biology·Liling SuGuangdi Chen
Jan 25, 2020·International Journal of Radiation Biology·Mohsen SisakhtZahra Khoshdel
Sep 5, 2020·International Journal of Environmental Health Research·Shiwangi GuptaRajeev Singh
Apr 7, 2018·Neural Regeneration Research·Xue-Feng DingYong-Qi Zhao
Apr 24, 2019·Environmental Science and Pollution Research International·Hui WangRuiyun Peng
Apr 30, 2017·Metabolic Brain Disease·Haifa OthmanHafedh Abdelmelek
Jun 29, 2017·International Journal of Oncology·Lennart Hardell
Oct 10, 2020·Environmental Research·Ranjeet KumarBasu Dev Banerjee
Feb 19, 2021·Military Medical Research·Yun-Fei LaiRui-Yun Peng
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gwladys Temkou NgoupayeElisabeth Ngo Bum

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Methods Mentioned

BETA
Assay
electrophoresis

Software Mentioned

Komet

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