Cognitive Impairment in Chronic Kidney Disease: Vascular Milieu and the Potential Therapeutic Role of Exercise

BioMed Research International
Ulf G BronasMary Hannan

Abstract

Chronic kidney disease (CKD) is considered a model of accelerated aging. More specifically, CKD leads to reduced physical functioning and increased frailty, increased vascular dysfunction, vascular calcification and arterial stiffness, high levels of systemic inflammation, and oxidative stress, as well as increased cognitive impairment. Increasing evidence suggests that the cognitive impairment associated with CKD may be related to cerebral small vessel disease and overall impairment in white matter integrity. The triad of poor physical function, vascular dysfunction, and cognitive impairment places patients living with CKD at an increased risk for loss of independence, poor health-related quality of life, morbidity, and mortality. The purpose of this review is to discuss the available evidence of cerebrovascular-renal axis and its interconnection with early and accelerated cognitive impairment in patients with CKD and the plausible role of exercise as a therapeutic modality. Understanding the cerebrovascular-renal axis pathophysiological link and its interconnection with physical function is important for clinicians in order to minimize the risk of loss of independence and improve quality of life in patients with CKD.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1996·Journal of the American Geriatrics Society·K OkumiyaT Ozawa
Dec 1, 1995·Journal of the Neurological Sciences·G FazekasG J Krejs
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A LiptonJ S Stamler
Jul 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A R SehgalP J Whitehouse
Jan 7, 1998·Archives of Psychiatric Nursing·E SteemanJ Godderis
Aug 26, 1998·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·B A BremerA Weaver
Aug 26, 1998·Journal of Gerontological Nursing·A Phinney
May 20, 1999·Lancet·K FassbenderM Hennerici
Oct 19, 2000·Journal of the American Geriatrics Society·C BerrA Alpérovitch
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Feb 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dirk W DrosteE Bernd Ringelstein
May 8, 2002·International Journal of Geriatric Psychiatry·Sandrine AndrieuBruno Vellas
Oct 3, 2002·Clinical Nephrology·T A IkizlerJ Himmelfarb
Dec 14, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eduard A IliescuWilma M Hopman
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·J M WardlawJ Starr
May 6, 2003·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Robert NewcomerKristine Yaffe
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Stephen L SeligerCatherine O Stehman-Breen
Oct 9, 2003·Mayo Clinic Proceedings·David S KnopmanRonald C Petersen
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stanley J ColcombeSteriani Elavsky
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Jennifer WeuveFrancine Grodstein
Oct 28, 2004·Journal of the American Geriatrics Society·Manjula KurellaKristine Yaffe
Nov 30, 2004·Clinical Neurology and Neurosurgery·R Brouns, P P De Deyn
Feb 8, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manjula KurellaGlenn M Chertow
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Clinton B WrightCharles DeCarli
May 13, 2005·Journal of the American Society of Nephrology : JASN·Manjula KurellaKristine Yaffe
Jun 6, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manjula KurellaGlenn M Chertow
Jun 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shahar LaviGiris Jacob
Jun 27, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ru-Lan HsiehChung-Hsin Chang
Jul 26, 2006·Neurology·A M MurrayR L Kane
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·Stephen L Seliger, W T Longstreth
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler
Feb 7, 2008·Seminars in Dialysis·Magdalena MaderoMark J Sarnak
May 23, 2008·Annals of Neurology·Kristine YaffeManjula Kurella-Tamura
Jul 1, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manjula Kurella TamuraWilliam McClellan
Aug 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mayumi KobayashiSatoshi Umemura
Sep 5, 2008·JAMA : the Journal of the American Medical Association·Nicola T LautenschlagerOsvaldo P Almeida
Dec 17, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Daniel E WeinerMark J Sarnak

❮ Previous
Next ❯

Citations

Oct 10, 2018·The Journal of Clinical Hypertension·Vladimir HachinskiUNKNOWN World Stroke Organization, the World Heart Federation, the World Hypertension League, the European Society of Hypertension
Oct 18, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Vladimir HachinskiWerner Hacke
Mar 1, 2019·Medicine and Science in Sports and Exercise·Ulf G BronasMelissa Lamar
Aug 18, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Jyotish Chalil GopinathanN A Uvais
Sep 10, 2020·Aging Clinical and Experimental Research·Mary HannanUlf G Bronas
Apr 24, 2018·BioMed Research International·Scott McGuireGordon McGregor
Jul 7, 2018·Canadian Journal of Kidney Health and Disease·David M KepecsDarren A Yuen
Sep 12, 2020·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Tara O'BrienDonna Hathaway
Aug 20, 2019·Free Radical Biology & Medicine·Mariam El AssarLeocadio Rodríguez-Mañas
Jan 29, 2021·Journal of Applied Physiology·Scott McGuireGordon McGregor
May 28, 2021·Neuropsychiatric Disease and Treatment·Yibeltal Yismaw GelaYigizie Yeshaw
Dec 17, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Asam Murtaza, Indranil Dasgupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
Manisha Jhamb, Daniel E Weiner
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Ziad MassyJ C Mazière
Current Opinion in Nephrology and Hypertension
Ziad Massy, Tilman B Drüeke
© 2022 Meta ULC. All rights reserved