Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study

Archives of General Psychiatry
W G van GorpW Dixon

Abstract

Few studies of the neurocognitive performance of patients with bipolar disorder have been performed while patients are in the euthymic state. Twenty-five euthymic bipolar patients (12 with and 13 without a history of alcohol dependence) were compared with 22 normal control subjects on a neuropsychological test battery assessing a range of cognitive domains. The relationship between subjects' neurocognitive performance and the course-of-illness variables (lifetime episodes and duration of mania, depression, or both), as well as current lithium level, was determined. The results indicated differences across the groups, with the bipolar patients with and without alcohol dependence performing more poorly than controls on tests of verbal memory. Furthermore, bipolar subjects with a history of alcohol dependence had additional decrements in executive (i.e., frontal lobe) functions when compared with controls. For subjects in the bipolar group, lifetime months of mania and depression were negatively correlated with performance in verbal memory and several executive function measures. Our findings support the presence of persistent neurocognitive difficulties in patients with long-standing bipolar disorder who are not in the psychiatri...Continue Reading

Citations

Aug 7, 2013·Pharmacology & Therapeutics·Margaret K KingEléonore Beurel
Apr 27, 2000·Acta Psychiatrica Scandinavica·L KrabbendamJ Jolles
May 9, 2006·Journal of Affective Disorders·Ritu NehraNitasha Khehra
May 9, 2006·Journal of Affective Disorders·Lucy J RobinsonP Brian Moore
Apr 26, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Kesavan MuralidharanLakshmi N Yatham
Mar 10, 2001·Acta Psychiatrica Scandinavica·G M MacQueenR T Joffe
Jun 13, 2002·Acta Psychiatrica Scandinavica·Glenda M MacQueenRussell T Joffe
May 3, 2001·Bipolar Disorders·K E Wilder-WillisS M Strakowski
Dec 18, 2013·European Archives of Psychiatry and Clinical Neuroscience·S MontelC Henry
Aug 23, 2008·Journal of Clinical and Experimental Neuropsychology·Michael R BassoRobert A Bornstein
Jul 21, 2005·Annals of General Psychiatry·Peter H SilverstoneAlan H Wilman
Jun 15, 2007·Schizophrenia Bulletin·Richard S E Keefe, Wayne S Fenton
Jun 1, 2006·Neuropsychiatric Disease and Treatment·Charles Bowden, Vivek Singh
Sep 22, 2009·Schizophrenia Bulletin·Emre BoraChristos Pantelis
Feb 16, 2010·Journal of Addictive Diseases·Natascha Wilson, Jean Lud Cadet
Apr 28, 2010·Journal of Psychiatry & Neuroscience : JPN·Sara K OlssonMikael Landén
Jan 1, 2006·Indian Journal of Psychiatry·J K Trivedi
Aug 25, 2007·Annual Review of Clinical Psychology·Michael F Green
Apr 26, 2000·Journal of Consulting and Clinical Psychology·C HammenL Altshuler
Mar 22, 2005·The Australian and New Zealand Journal of Psychiatry·Antoni BenabarreManuel Valdés
Sep 21, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Sanja Totić-PoznanovićVladimir R Paunović
Apr 1, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·I-Chao LiuTsung-Tsair Yang
Mar 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Koji MatsuoJair C Soares
Jun 1, 2013·Psychiatry Research·Daniel F HermensIan B Hickie
Nov 27, 2002·Journal of Affective Disorders·Seema Quraishi, Sophia Frangou
Sep 8, 2007·Journal of Child and Adolescent Psychopharmacology·Rene L OlveraJair C Soares
Jul 17, 2010·Applied Psychophysiology and Biofeedback·Estate M SokhadzeRif S El-Mallakh
Apr 2, 2008·International Psychogeriatrics·Marcia RadanovicOrestes Vicente Forlenza
Jun 21, 2005·Journal of the International Neuropsychological Society : JINS·Eric R LarsonStephen M Strakowski
Feb 28, 2008·Cognitive Neuropsychiatry·J K TrivediRajul Tandon
Oct 24, 2012·Cognitive Neuropsychiatry·Tamsyn E Van Rheenen, Susan L Rossell
May 4, 2010·Journal of Mental Health·Lena Palaniyappan, David Andrew Cousins
Apr 28, 2005·Expert Review of Neurotherapeutics·Michael Gitlin
Apr 21, 2006·Expert Review of Neurotherapeutics·Catherine M CahillMartin Cohen
Feb 14, 2016·Journal of Affective Disorders·Lindsay C HanfordGeoffrey B Hall
May 22, 2010·Expert Opinion on Emerging Drugs·Marsal SanchesJair C Soares
May 21, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Inés AncínAna Barabash
Jan 23, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Young Sup WooRoger S McIntyre
Dec 29, 2015·Psychiatry Research·David F MarshallScott A Langenecker
Sep 5, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·B J HasselbalchL V Kessing

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
Luke ClarkGuy M Goodwin
European Psychiatry : the Journal of the Association of European Psychiatrists
G FaberR J Van Den Bosch
© 2021 Meta ULC. All rights reserved