Cognitive impairment in Glucocerebrosidase (GBA)-associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles

Movement Disorders : Official Journal of the Movement Disorder Society
Stefanie LercheKathrin Brockmann

Abstract

A proportion of idiopathic Parkinson's disease patients (PDidiopathic ) with dementia show altered CSF profiles of amyloid β (Aβ) and Tau. PD patients with Glucocerebrosidase (GBA) mutations (PDGBA ) present with even more cognitive decline than seen in PDidiopathic . The objective of this study was to evaluate whether CSF profiles of Aβ and tau are associated with the prominent cognitive impairment in PDGBA . CSF levels of Aβ1-42 , t-Tau, p-Tau, and total alpha-synuclein were assessed in 479 participants (50 PDGBA , 308 PDidiopathic , 121 healthy controls). Older age was associated with cognitive impairment in PDGBA and PDidiopathic . Despite prominent cognitive impairment, PDGBA showed similar CSF levels of Aβ1-42 , t-Tau, and p-Tau as seen in healthy controls. In contrast, lower levels of Aβ1-42 and higher levels of t-Tau and p-Tau were associated with worse cognitive performance in PDidiopathic . The prominent cognitive impairment in PDGBA seems not primarily associated with Aβ and Tau profiles in CSF. © 2017 International Parkinson and Movement Disorder Society.

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Citations

Mar 8, 2018·BMC Medicine·Kurt A Jellinger, Amos D Korczyn
Feb 23, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Roy N AlcalayZiv Gan-Or
Jun 13, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Stefanie LercheKathrin Brockmann
Feb 27, 2020·Journal of Clinical Medicine·Silvia PaciottiTommaso Beccari
Nov 2, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Stefanie LercheKathrin Brockmann
Feb 20, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Tanya SimuniUNKNOWN Parkinson's Progression Markers Initiative Investigators
Oct 24, 2020·Neurology·Andrea PilottoDaniela Berg
Oct 2, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Silvia Paola CaminitiDaniela Perani
Dec 25, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Jingru RenWeiguo Liu

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