PMID: 24359878Dec 24, 2013Paper

Cognitive impairment with and without depression history: an analysis of white matter microstructure

Journal of Psychiatry & Neuroscience : JPN
Shantel L DuffyJim Lagopoulos

Abstract

Mild cognitive impairment (MCI) and late-life depression are clinical syndromes that often co-occur and may represent an early manifestation of neurodegenerative disease. The present study examined white matter microstructure in patients with MCI with and without a history of major depression compared with healthy controls. Older adults with MCI and no history of major depression (MCI), adults with MCI and euthymic major depression (MCI-MD) and healthy controls underwent comprehensive medical, psychiatric and neuropsychological assessments. Participants also underwent diffusion tensor imaging, which was analyzed using tract-based spatial statistics. White matter hyperintensity (WMH) burden and medical burden were also quantified. We enrolled 30 participants in the MCI group, 36 in the MCI-MD group and 22 in the control group. Compared with controls, participants in the MCI group had significantly reduced fractional anisotropy (FA) in the corpus callosum, superior longitudinal fasciculus (SLF), corona radiata and posterior thalamic radiation. Participants in the MCI-MD group had significantly reduced FA in the corpus callosum, internal capsule, external capsule, corona radiata, posterior thalamic radiation, sagittal striatum, fo...Continue Reading

Citations

Sep 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gil ZalsmanAron Weller
Dec 17, 2014·PloS One·Sri C KanchibhotlaPerminder S Sachdev

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