Cognitive impairments and low BDNF serum levels in first-episode drug-naive patients with schizophrenia

Psychiatry Research
Lijuan ManXiang Yang Zhang

Abstract

Evidence shows that BDNF may regulate activity-dependent forms of synaptic plasticity underlying learning and memory. Previous studies reported low BDNF levels and cognitive impairment in the early stage of schizophrenia. Our current study aimed to explore the association between serum BDNF and cognitive functions in first-episode drug-naïve (FEDN) patients with schizophrenia, which has been under-investigated. We recruited 80 FEDN patients and 80 healthy controls and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum BDNF in both groups. Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). BDNF levels were significantly lower in patients compared to controls (p < 0.001). The RBANS total score and nearly all indexes (all p < 0.001) except for visuospatial/constructional index (p > 0.05) were significantly lower in patients than controls. No significant correlation was found between BDNF and any index or total scores of RBANS in either patients or healthy controls (all p > 0.05). However, the PANSS negative subscale score were negatively associated with both the immediate memory and language indexes (both p < 0.005). Our findings suggest that ...Continue Reading

References

Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·C RandolphT N Chase
Dec 6, 2000·Progress in Brain Research·B Lu, W Gottschalk
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Oct 12, 2001·Schizophrenia Research·N DuranyJ Thome
Jul 20, 2002·Psychiatry Research·Kazuhiko ToyookaHiroyuki Nawa
Nov 5, 2002·Schizophrenia Research·Catherine HughesTonmoy Sharma
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sebnem PirildarFisun Akdeniz
Sep 15, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·Nuria Durany, Johannes Thome
Nov 9, 2004·Schizophrenia Research·Keith H NuechterleinRobert K Heaton
Nov 9, 2004·Schizophrenia Research·Michael F GreenRobert K Heaton
Apr 12, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gal Shoval, Abraham Weizman
Jul 11, 2006·Schizophrenia Research·Aitor PalominoCarlos Matute
Nov 11, 2006·Journal of Psychiatric Research·Xiang Yang ZhangThomas R Kosten
Jun 6, 2007·Archives of General Psychiatry·Richard S E KeefeUNKNOWN Neurocognitive Working Group
May 27, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·E N RizosL Lykouras
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Jul 30, 2009·Neuropsychology Review·Barton W PalmerRobert K Heaton
Sep 2, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mei Hong XiuXiang Yang Zhang
Nov 28, 2009·The International Journal of Neuropsychopharmacology·Anilkumar PillaiSahebarao P Mahadik
Jul 28, 2010·Psychopharmacology·Xiang Yang ZhangThomas R Kosten
Jan 21, 2011·Current Opinion in Psychiatry·Peter F BuckleyKristy R Howell
Sep 21, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomihisa NiitsuMasaomi Iyo
Oct 28, 2011·Journal of Psychiatric Research·Gabriela FavalliZafiris Jeffrey Daskalakis
Jan 26, 2012·Psychopharmacology·Xiang Yang ZhangThomas R Kosten
Aug 30, 2012·The Psychiatric Clinics of North America·Anilkumar Pillai, Peter F Buckley
Sep 25, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·R AndersenB Glenthoj
Dec 18, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Davide CarlinoEnrico Tongiorgi
Mar 19, 2013·Brain, Behavior, and Immunity·Xiang Yang ZhangThomas R Kosten
Mar 29, 2014·Handbook of Experimental Pharmacology·B LuY Lu

❮ Previous
Next ❯

Citations

Jun 26, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ulrike HeitzAnita Riecher-Rössler
Nov 7, 2019·Journal of Clinical Psychopharmacology·Jie Yin YeeJimmy Lee
Aug 30, 2019·Psychiatric Genetics·Pasquale Di CarloGianluca Ursini
Apr 22, 2021·International Journal of Psychiatry in Clinical Practice·Rongrong ZhuXiang Yang Zhang
May 30, 2021·Cognitive, Affective & Behavioral Neuroscience·Yossi GutermanSteven M Silverstein
Jul 6, 2021·Frontiers in Psychiatry·Rodrigo R NietoHernan Silva
Dec 18, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dong Mei WangXiang Yang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here