Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1 receptors

Proceedings of the National Academy of Sciences of the United States of America
Eva-Maria ElmenhorstDaniel Aeschbach

Abstract

Trait-like differences in cognitive performance after sleep loss put some individuals more at risk than others, the basis of such disparities remaining largely unknown. Similarly, interindividual differences in impairment in response to alcohol intake have been observed. We tested whether performance impairments due to either acute or chronic sleep loss can be predicted by an individual's vulnerability to acute alcohol intake. Also, we used positron emission tomography (PET) to test whether acute alcohol infusion results in an up-regulation of cerebral A1 adenosine receptors (A1ARs), similar to the changes previously observed following sleep deprivation. Sustained attention in the psychomotor vigilance task (PVT) was tested in 49 healthy volunteers (26 ± 5 SD years; 15 females) (i) under baseline conditions: (ii) after ethanol intake, and after either (iii) total sleep deprivation (TSD; 35 hours awake; n = 35) or (iv) partial sleep deprivation (PSD; four nights with 5 hours scheduled sleep; n = 14). Ethanol- versus placebo-induced changes in cerebral A1AR availability were measured in 10 healthy male volunteers (31 ± 9 years) with [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX) PET. Highly significant correlation...Continue Reading

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Citations

Apr 18, 2019·Behavioral and Brain Functions : BBF·Gregory L EngelAmanda J Crocker
Jul 25, 2019·CNS Neuroscience & Therapeutics·Ying-Jiao LiuNai-Hong Chen
Jul 31, 2019·Journal of Neurochemistry·Dietrich van CalkerTsvetan Serchov
Feb 11, 2020·International Reviews of Immunology·Marharyta Zyma, Rafał Pawliczak
May 29, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E K EricksonR A Harris
Apr 5, 2019·Journal of Caffeine and Adenosine Research·Sergi Ferré
Dec 30, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Diego M BaurHans-Peter Landolt
Apr 21, 2021·Journal of Biological Rhythms·Dorothee FischerCéline Vetter

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