Cognitive impulsivity in animal models: role of response time and reinforcing rate in delay intolerance with two-choice operant tasks

Neuropharmacology
Walter AdrianiGiovanni Laviola

Abstract

Impulsivity, a key symptom of ADHD (attention-deficit hyperactivity disorder), is also common in obsessive-compulsive and addictive disorders. There is rising interest in animal models of inhibitory-control impairment. Adolescent rats were tested daily in the intolerance-to-delay (ID) task (session 25 min, timeout 20 s), involving choice between either immediate small amount of food (SS), or larger amount of food after a delay (LL). The mixed 5-HT(1A/7) agonist (8-OH-DPAT, 0 or 0.060 mg/kg i.p.) was administered acutely just before the last three sessions at highest delays. In addition to the classical choice parameter (percent LL preference), the spontaneous waiting (termed response time, RT) occurring between end of a timeout (TO) and next nose-poke was calculated. The pace between consecutive reinforcer deliveries is given by the mean inter-trial interval (mITI, i.e. TO + RT). Hence, the impact of any given delay may be proportional to this pace and be expressed as delay-equivalent odds, i.e. the extent by which delays are multiples of the mITI. Data revealed that RT/mITI increased sharply from around 15 s/35 s to around 30 s/50 s when imposed delay changed from 30 s to 45 s (i.e. odds from 0.91 to 1.06). This suggests that ...Continue Reading

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Citations

Aug 15, 2012·Behavioral Neuroscience·Tamara L Doremus-FitzwaterLinda P Spear
Mar 8, 2011·Neuroscience and Biobehavioral Reviews·Eva M MarcoGiovanni Laviola
Jan 19, 2012·Developmental Psychobiology·Mariana SchroederAron Weller
Apr 12, 2012·British Journal of Pharmacology·Francisco NavarreteJorge Manzanares
Apr 15, 2015·Frontiers in Aging Neuroscience·Yannick-André BretonA David Redish
Nov 11, 2019·The Journal of Physiological Sciences : JPS·Fumika AkizawaMunetaka Shidara

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