PMID: 9658380Jul 11, 1998Paper

Cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice

Methods and Findings in Experimental and Clinical Pharmacology
K OnoderaM Imaizumi

Abstract

In this study, the intracerebroventricular administration of 4-methylhistamine (3 and 10 micrograms/head), a histamine H2 receptor agonist, shortened the step-through latency in the retention trial using a step-through passive avoidance task in mice. This deteriorating effect of 4-methylhistamine (3 micrograms/head) was clearly antagonized by pretreatment with zolantidine (10 mg/kg, i.p.), a histamine H2 receptor antagonist, 20 min before an acquisition trial. Zolantidine alone at the dose tested had no effect. Thus, it is likely that activation of histamine H2 receptors has a deteriorating effect on avoidance learning in mice. The present results indicate the cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice.

Citations

Jan 12, 2010·Behavioural Brain Research·E DereJ P Huston
Aug 31, 2011·Neural Plasticity·Cristiano André KöhlerJuliana Sartori Bonini
Apr 25, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Luciana Pereira do Vale Cofiel, Rosana Mattioli
Mar 8, 2002·Alzheimer Disease and Associated Disorders·Michelle C CarlsonJohn C S Breitner

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