Cognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children

NeuroImage
Stefan HeimKatrin Amunts

Abstract

Recent theories of developmental dyslexia explain reading deficits in terms of deficient phonological awareness, attention, visual and auditory processing, or automaticity. Since dyslexia has a neurobiological basis, the question arises how the reader's proficiency in these cognitive variables affects the brain regions involved in visual word recognition. This question was addressed in two fMRI experiments with 19 normally reading children (Experiment 1) and 19 children with dyslexia (Experiment 2). First, reading-specific brain activation was assessed by contrasting the BOLD signal for reading aloud words vs. overtly naming pictures of real objects. Next, ANCOVAs with brain activation during reading the individuals' scores for all five cognitive variables assessed outside the scanner as covariates were performed. Whereas the normal readers' brain activation during reading showed co-variation effects predominantly in the right hemisphere, the reverse pattern was observed for the dyslexics. In particular, middle frontal gyrus, inferior parietal cortex, and precuneus showed contralateral effects for controls as compared to dyslexics. In line with earlier findings in the literature, these data hint at a global change in hemispheri...Continue Reading

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Citations

Jun 19, 2013·Brain Structure & Function·Katarzyna JednorógAnna Grabowska
Oct 17, 2015·Perceptual and Motor Skills·David S MatherLona M Mcrae
Mar 5, 2016·Frontiers in Pediatrics·Eleni A Papagiannopoulou, Jim Lagopoulos
Jan 1, 2013·NeuroImage. Clinical·Muna van Ermingen-MarbachStefan Heim
Jan 11, 2012·Brain and Language·Stefan HeimKatrin Amunts
Jan 8, 2014·Arquivos de neuro-psiquiatria·Paulina C Murphy-RuizAdrián Poblano
Dec 7, 2018·Language, Cognition and Neuroscience·Clinton L JohnsDavid Braze

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