Cognitive load and autonomic response patterns under negative priming demand in depersonalization-derealization disorder

The European Journal of Neuroscience
Erwin LemcheVincent P Giampietro

Abstract

Previous studies have yielded evidence for cognitive processing abnormalities and alterations of autonomic functioning in depersonalization-derealization disorder (DPRD). However, multimodal neuroimaging and psychophysiology studies have not yet been conducted to test for functional and effective connectivity under cognitive stress in patients with DPRD. DPRD and non-referred control subjects underwent a combined Stroop/negative priming task, and the neural correlates of Stroop interference effect, negative priming effect, error rates, cognitive load span and average amplitude of skin conductance responses were ascertained for both groups. Evoked haemodynamic responses for basic Stroop/negative priming activations were compared. For basic Stroop to neutral contrast, patients with DPRD differed in the location (inferior vs. superior lobule) of the parietal region involved, but showed similar activations in the left frontal region. In addition, patients with DPRD also co-activated the dorsomedial prefrontal cortex (BA9) and posterior cingulate cortex (BA31), which were also found to be the main between-group difference regions. These regions furthermore showed connectivity with frequency of depersonalization states. Evoked haemod...Continue Reading

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Citations

Mar 27, 2018·Current Behavioral Neuroscience Reports·Annegret Krause-Utz, Bernet Elzinga
Apr 26, 2020·Psychology and Psychotherapy·Miriam Vannikov-LugassiNirit Soffer-Dudek
Feb 1, 2017·Current Psychiatry Reports·Annegret Krause-UtzBernet M Elzinga
Aug 3, 2020·Journal of Affective Disorders·Mathilde HornFabien D'Hondt
Dec 4, 2020·Neuroscience and Biobehavioral Reviews·Monika I Roydeva, Antje A T S Reinders

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Methods Mentioned

BETA
SMA

Software Mentioned

SC
ANALYZE
ancova
μSiemens
XBAM

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