Cognitive outcome after awake surgery for tumors in language areas.

Journal of Neuro-oncology
B SantiniG Miceli

Abstract

In surgery for tumors of the dominant hemisphere, the attention devoted to quality of resection and preservation of language function has not been accompanied by comparable interest in preservation of cognitive abilities which may affect quality of life. We studied 22 patients undergoing awake surgery for glioma removal in the language areas of the brain. Besides monitoring tumor variables (size, location, histology, edema), we used a multifaceted battery of tests to investigate mood, cognition, and language in an attempt to assess the burden of disease and treatment, and the relationships between these three dimensions. Baseline assessment showed that 45% of the patients were depressed and 23% anxious; some cognitive and language impairment was noted for 59 and 50%, respectively. A general decline in postoperative cognitive performance (significant for memory and attention only) and language function (significant for picture naming) was observed, whereas depression was unchanged and anxiety decreased. Tumor histology, but not demographic variables or extent of resection, correlated with postoperative cognitive changes: patients undergoing surgery for high-grade tumors were more likely to improve. No correlation was observed be...Continue Reading

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Citations

Nov 1, 2013·Journal of Neuro-oncology·Djaina SatoerArnaud Vincent
Jun 1, 2014·Acta neurochirurgica·Esther J J HabetsMartin J B Taphoorn
Feb 3, 2016·Journal of Neuro-oncology·Juliane BeckerSimone Goebel
Apr 1, 2016·Langenbeck's Archives of Surgery·Julia WolfRezvan Ahmadi
Aug 2, 2018·Journal of Clinical and Experimental Neuropsychology·Carla Ruis
Dec 24, 2018·Neuropsychology Review·Fleur van IerschotGabriele Miceli
Sep 14, 2019·Cognitive Neuropsychology·Bradford Z MahonWebster H Pilcher
Jul 7, 2020·Neuro-oncology Practice·Rohitashwa SinhaStephen John Price
Feb 22, 2012·Journal of Neuro-oncology·G MiceliA Talacchi
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Mar 24, 2018·Journal of Neurosurgery·Ori BarzilaiZvi Ram
Feb 1, 2018·Journal of Clinical and Experimental Neuropsychology·Adrià RofesGabriele Miceli
Feb 27, 2013·Acta neurochirurgica·Djaina SatoerEvy Visch-Brink
Feb 8, 2018·International Journal of Language & Communication Disorders·Malin AntonssonÅsa Wengelin
Apr 17, 2014·Neuropsychology Review·Adrià Rofes, Gabriele Miceli
Nov 15, 2015·Acta neurochirurgica·Djaina SatoerArnaud Vincent
Feb 12, 2021·Journal of Clinical Medicine·Katharina RosengarthChristian Doenitz
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Mar 20, 2021·Scientific Reports·Alexander A AabediShawn L Hervey-Jumper
Apr 27, 2021·Neuro-oncology Practice·Christina Weyer-JamoraJennie W Taylor

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