Cognitive outcome of pediatric epilepsy surgery across ages and different types of surgeries: A monocentric 1-year follow-up study in 306 patients of school age

Seizure : the Journal of the British Epilepsy Association
C HelmstaedterC Hoppe

Abstract

The neuropsychological outcome of pediatric epilepsy surgery has been reported before, but only few studies compared different major types of surgery in differentially located epilepsies. Neuropsychological performance of 306 children and adolescents (ages 6-17 years) were assessed before and one year after epilepsy surgery. Individual impairments, changes into and out of impairment, as well as intraindividually meaningful positive or negative changes were examined. Regression analyses addressed the effects of site, side, pathology, type of surgery, seizure outcome, and drug change on the cognitive and behavioral domains. Preoperatively 85% of the patients had cognitive impairments in at least one domain, 71% had behavioral problems. Postoperatively the number of impaired patients dropped considerably: 21-50% of the patients changed from impaired to unimpaired, individually significant gains were registered in 16-42%. Seizure freedom was achieved in 81% of all patients. The number of antiepileptic drugs decreased significantly. Seizure freedom, a younger age at evaluation, a later age at onset, a lower antiepileptic drug load, and less baseline damage predict better cognitive and behavioral outcomes. Gender, pathology, localiza...Continue Reading

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Citations

Dec 11, 2020·Scientific Reports·Anne Margarette S MaalloMarlene Behrmann
Dec 28, 2019·Seizure : the Journal of the British Epilepsy Association·Jun T Park
Jul 24, 2021·Seizure : the Journal of the British Epilepsy Association·Virginie LaguittonNathalie Villeneuve
Jul 1, 2020·Seizure : the Journal of the British Epilepsy Association·Kullasate SakpichaisakulRavindra Arya

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